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WST11\u2010VTP utilizes illumination, leading to hypoxia, and production of free radicals followed by coagulative necrosis. Here, we tested the hypothesis that WST11\u2010VTP can safely ablate muscle\u2010invasive MB\u201049\u2010 luc bladder tumors in an orthotopic mouse model while sparing the surrounding normal tissue. For the safety study, normal mouse bladders were WST11\u2010VTP treated. Fourteen days post\u2010VTP granulomas in local areas around the ablation zone were noticed, which recovered after 44\u2009days. MB49\u2010luc orthotopic tumors at the muscle\u2010invasive stage appeared to be effectively ablated by VTP 4\u201310\u2009days post\u2010treatment. The anti\u2010tumor response was reflected in the increased invasion of CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup> T cells, myeloid CD11b<jats:sup>+<\/jats:sup> cells, and NK cells in tumor tissue at 7\u2009days post\u2010therapy. Moreover, VTP therapy prolonged the survival of mice bearing orthotopic tumors compared with the untreated control. These results suggest that VTP can selectively ablate malignant tumors in the bladder and promote a robust anti\u2010tumor response in a mouse model that can further augment the therapeutic outcome.<\/jats:p>","DOI":"10.1111\/php.14048","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:39:08Z","timestamp":1741736348000},"page":"1317-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Selectivity and anti\u2010tumor immune elevation by vascular\u2010targeted photodynamic therapy of mouse orthotopic bladder cancer model"],"prefix":"10.1111","volume":"101","author":[{"given":"Jie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Research Center  New York New York 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