{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:11:19Z","timestamp":1784311879321,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006402","name":"Fasa University of Medical Sciences","doi-asserted-by":"publisher","award":["401166"],"award-info":[{"award-number":["401166"]}],"id":[{"id":"10.13039\/501100006402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp;amp; Photobiology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    While aging inevitably changes our skin, this complex biological process involves much more than just getting older. As the body's largest organ, the skin constantly safeguards us from harmful environmental pathogens and plays a key role in overall well\u2010being. This study investigated the development and evaluation of a nanogel containing\n                    <jats:italic>Rosa damascena<\/jats:italic>\n                    essential oil for its potential anti\u2010aging properties. The nanogel was prepared from a primary nanoemulsion with a particle size of 86\u2009\u00b1\u20094\u2009nm. Antioxidant activity, measured using the 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) assay, was found to be 76%\u2009\u00b1\u20093%. Furthermore, the nanogel demonstrated superior anti\u2010collagenase and anti\u2010elastase activities (60%\u2009\u00b1\u20092% and 51%\u2009\u00b1\u20090.1%, respectively) compared to the essential oil alone. The antibacterial efficacy of the nanogel was tested against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , revealing potent inhibitory effects. To simulate the aging process, rats were subjected to UVB irradiation on both legs 4\u2009days a week before or after treatment. In\u00a0vivo studies conducted on mice showed that the nanogel effectively reduced the formation of deep wrinkles in treated groups compared to pretreated ones. These findings suggest that the introduced nanogel, with its antioxidant and antimicrobial properties, holds promise as a natural therapeutic approach for wrinkle treatment.\n                  <\/jats:p>","DOI":"10.1111\/php.14072","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T04:44:56Z","timestamp":1738212296000},"page":"1443-1453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigating the protective effect of\n                    <i>Rosa damascena<\/i>\n                    nanogel on collagenase and elastase activity and\n                    <scp>UVB<\/scp>\n                    \u2010induced dermal damage: A rodent model approach to skin photoaging"],"prefix":"10.1111","volume":"101","author":[{"given":"Negar","family":"Ranjbar","sequence":"first","affiliation":[{"name":"Student Research Committee Fasa University of Medical Sciences  Fasa Iran"},{"name":"Department of Medicine, School of Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1190-6874","authenticated-orcid":false,"given":"Mahmoud","family":"Osanloo","sequence":"additional","affiliation":[{"name":"Department of Medical Nanotechnology, School of Advanced Technologies in Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Nasiri\u2010Ghiri","sequence":"additional","affiliation":[{"name":"Student Research Committee Fasa University of Medical Sciences  Fasa Iran"},{"name":"Department of Medical Biotechnology, School of Advanced Technologies in Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zarenezhad","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roghayeh","family":"Heiran","sequence":"additional","affiliation":[{"name":"Estahban Higher Education Center\u2010Shiraz University  Estahban Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghanbariasad","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Advanced Technologies in Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmeh","family":"Namdar","sequence":"additional","affiliation":[{"name":"Department of Tissue Engineering, School of Advanced Technology in Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-0912","authenticated-orcid":false,"given":"Hiva","family":"Alipanah","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center Fasa University of Medical Sciences  Fasa Iran"},{"name":"Department of Physiology, School of Medicine Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"1","article-title":"In vitro screening of elastase, collagenase, hyaluronidase, and tyrosinase inhibitory and antioxidant activities of 22 halophyte plant extracts for novel cosmeceuticals","volume":"23","author":"Jiratchayamaethasakul C","year":"2020","journal-title":"Fisher Aquat Sci"},{"issue":"3","key":"e_1_2_14_3_1","first-page":"409","article-title":"Formulation and evaluation of antiaging phytosomal gel. 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