{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:32:50Z","timestamp":1783571570310,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["91801932"],"award-info":[{"award-number":["91801932"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/12120\u20104"],"award-info":[{"award-number":["2020\/12120\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/15943\u20101"],"award-info":[{"award-number":["2020\/15943\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/18483\u20101"],"award-info":[{"award-number":["2018\/18483\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp;amp; Photobiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our study aimed to explore the potential of Photobiomodulation (PBM) as a treatment for Tendinopathy (TP), a chronic condition characterized by tendon degeneration, inflammation, and pain, for which current treatment options often yield unsatisfactory outcomes. PBM, utilizing low\u2010level laser, has shown promise in reducing inflammatory markers, stimulating cell proliferation, and alleviating pain, thus presenting itself as a promising alternative therapy for TP. Using an experimental rat model of tendinopathy, male Wistar rats weighing 250\u2013370\u2009g were induced with TP through the injection of type I collagenase into the calcaneal tendon. Animals were divided into four equal groups (control, TP, TP\u2009+\u2009660\u2009nm, TP\u2009+\u2009808\u2009nm), with 10 animals in each group for the nociceptive behavioral tests and 5 in each for the biomolecular analysis. Fifteen days later, PBM was administered to the tendons once daily for seven consecutive sessions using two wavelengths (660 and 808\u2009nm), with 3\u2009J for 30\u2009s, irradiating an area of 0.028\u2009cm<jats:sup>2<\/jats:sup> totaling 107.14\u2009J\/cm<jats:sup>2<\/jats:sup>. Mechanical nociception and thermal cold sensitivity were assessed, and tendon samples were collected for analysis of collagen types and total cell count. Spinal cord samples were also collected and immunostained to evaluate specific markers. Our results demonstrated that collagenase injection induced mechanical allodynia and cold hypersensitivity, both of which were reversed by PBM at both 660 and 808\u2009nm wavelengths (**<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005 and *<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, TP led to an increase in collagen type III and a decrease in collagen type I expression, with these effects being reversed by PBM treatment (*<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, TP increased astrocyte immunoreactivity, while PBM at both wavelengths led to a decrease in astrocyte and IL\u20101\u03b2 expression. In conclusion, PBM emerged as an effective treatment for TP, as it not only alleviated pain symptoms but also modulated collagen expression and reduced astrocyte and IL\u20101\u03b2 expression (**<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). These findings suggest that PBM could serve as a beneficial adjunctive therapy for analgesia and regeneration in TP management.<\/jats:p>","DOI":"10.1111\/php.14082","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:08:27Z","timestamp":1742371707000},"page":"925-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reversal of allodynia and enhanced tendon repair in rats via 660 and 808\u2009nm photobiomodulation"],"prefix":"10.1111","volume":"101","author":[{"given":"Elia Francesco","family":"Vedda","sequence":"first","affiliation":[{"name":"Department of Anatomy ICB\/USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helo\u00edsa Alonso","family":"Matielo","sequence":"additional","affiliation":[{"name":"Department of Anatomy ICB\/USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Corr\u00eaa","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Anatomy ICB\/USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victhor Teixeira","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Anatomy ICB\/USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vict\u00f3ria Regina","family":"da Silva Oliveira","sequence":"additional","affiliation":[{"name":"Department of Anatomy ICB\/USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilson Silva","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Physiology ICB\/USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Roberto Giorgetti","family":"Britto","sequence":"additional","affiliation":[{"name":"Department of Physiology ICB\/USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3421-7799","authenticated-orcid":false,"given":"Camila Squarzoni","family":"Dale","sequence":"additional","affiliation":[{"name":"Department of Anatomy ICB\/USP  S\u00e3o Paulo Brazil"},{"name":"Department of Surgical Technique FMUSP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450023348028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-091957"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-013-0096-z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1524-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136348"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06845"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.335802"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017643230376"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0604-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2093"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2010.10.013"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2019.4633"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4364"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2317-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161590"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000158471.41575.F0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1994.11.187"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20176681"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030820"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2011.00999.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22156"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2070-0"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201800110"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3051-05.2005"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/145749691009900315"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel046"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00259.2009"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2021.0192"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.14082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:01:51Z","timestamp":1755090111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.14082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/php.14082"],"URL":"https:\/\/doi.org\/10.1111\/php.14082","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"2024-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}