{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:06:15Z","timestamp":1785290775685,"version":"3.55.0"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp;amp; Photobiology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Plants may be a source of protective compounds that inhibit injuries caused by overexposure to solar radiation. Present work evaluated the protective effects of a phytochemical mixture based on\n                    <jats:italic>Posoqueria latifolia<\/jats:italic>\n                    extract + Kaempferol against ultraviolet\u2010induced radiation DNA damage in human fibroblasts and mice skin. Cytotoxicity, genotoxicity, and antigenotoxicity of\n                    <jats:italic>P. latifolia<\/jats:italic>\n                    flower extract, Kaempferol, and the mixture of both were studied in MRC5 human fibroblasts using Trypan blue exclusion and Comet assays. Kinetics of DNA damage repair post irradiation, in the presence and absence of the phytochemicals, were also evaluated. The inhibition of UVB\u2010induced erythema and cyclobutene pyrimidine dimers (CPD) by the phytochemicals and the mixture were also investigated in mice skin. We showed that the\n                    <jats:italic>P. latifolia<\/jats:italic>\n                    flower extract, Kaempferol, and the mixture inhibited UVB\u2010induced DNA damage and increased DNA repair mechanisms in human fibroblasts. In addition, these phytochemicals inhibited the UVB\u2010induced erythema and CPD in mice skin. The potential of the studied phytochemicals in human photoprotection was discussed.\n                  <\/jats:p>","DOI":"10.1111\/php.14086","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T19:18:11Z","timestamp":1743275891000},"page":"1454-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vitro and in\u00a0vivo protective effects of a phytochemical mixture (\n                    <i>Posoqueria latifolia<\/i>\n                    extract\u2009+\u2009Kaempferol) against\n                    <scp>UVB<\/scp>\n                    \u2010induced radiation damage\n                    <sup>*<\/sup>"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-647X","authenticated-orcid":false,"given":"Silvia Ximena","family":"Barrios Mart\u00ednez","sequence":"first","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda y Mutag\u00e9nesis 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Mutag\u00e9nesis Ambiental (LMMA), Grupo de Investigaci\u00f3n en Microbiolog\u00eda y Gen\u00e9tica, Escuela de Biolog\u00eda, Facultad de Ciencias Universidad Industrial de Santander (UIS)  Bucaramanga Colombia"},{"name":"Laboratorio de Cromatograf\u00eda, CROM\u2010MASS, Escuela de Qu\u00edmica Facultad de Ciencias, UIS  Bucaramanga Santander 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