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However, there is a limited and inconclusive study on the application of light\u2010emitting diode (LED) for nerve injury repair. In this study, we designed an 807\u2010nm LED device with high luminous uniformity to investigate the effects of LED\u2010based PBM on peripheral nerve injury repair. RSC96 cells were utilized as the target cells and optimal light parameters were selected based on ATP concentration, CCK\u20108 assays, PCR, and immunofluorescent staining. One\u2010way analysis of variance and Student's\n                    <jats:italic>t<\/jats:italic>\n                    \u2010test was used for statistical tests. LED irradiation at 10\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    for 30\u2009min effectively enhanced Schwann cell proliferation, neurotrophic factor secretion, and MBP synthesis. To translate the cellular light parameters for animal studies, the transmittance through freshly obtained rat skin and biceps femoris muscle was assessed, and the transmittance was approximately 30%. After directly daily irradiating the sciatic nerve injury area in rats for 21\u2009days at 33\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    for 30\u2009min, we used gait analysis, immunofluorescence staining, muscle wet weight ratio, Masson staining, and transmission electron microscopy to evaluate nerve recovery. LED irradiation significantly improved sciatic nerve index, increased MBP staining intensity, and enhanced myelin sheath thickness, nerve diameter, and axon diameter. These results indicated the feasibility of LED\u2010based PBM as a treatment method for peripheral nerve injuries.\n                  <\/jats:p>","DOI":"10.1111\/php.14090","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:57:33Z","timestamp":1741755453000},"page":"207-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of 807\u2010nm light\u2010emitting diode photobiomodulation on peripheral nerve injury"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-1720","authenticated-orcid":false,"given":"Biao","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Laser Medicine, The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Quan","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Laser Medicine, The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Guan","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Laser Medicine, The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Laser Medicine, The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laser Medicine, The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laser Medicine, The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing China"},{"name":"Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Laser Medicine, The First Medical Center Chinese PLA General Hospital  Beijing 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