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Its application has expanded significantly, particularly in the field of cancer therapy. This review provides a comprehensive overview of PBM, elucidating its underlying mechanisms of action and its potential applications in cancer therapy. It highlights the benefits of PBM in reducing side effects of cancer treatments such as acute oral mucositis, radiation dermatitis, lymphedema, neuropathic pain, and radiation enteropathy. Furthermore, the ability of PBM to inhibit cancer cell proliferation and induce apoptosis, and discusses safety concerns of PBM in clinical applications, presenting existing research that emphasizes its significant potential in cancer therapy was summarized. 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