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Although nonsurgical and surgical treatments can reduce the inflammatory process, the high prevalence of peri\u2010implantitis suggests that these interventions are not always effective in arresting disease progression. This has prompted increased interest in antimicrobial photodynamic therapy (aPDT), which utilizes photosensitizers (PSs) activated by light to target bacterial infections. Despite promising benefits, aPDT has not yet achieved consistently favorable clinical outcomes. It may be due to the limitations of current PSs, including restricted light activation, insufficient tissue penetration, and variable antimicrobial efficacy. Additionally, the stability and selectivity of PSs are crucial for their effectiveness against pathogenic bacteria. Variations in light delivery systems and treatment protocols may also contribute to inconsistent results across studies. 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