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Photobiomodulation (PBM) therapy in the red\/near\u2010infrared spectrum holds promising reparative potential; however, there are no consistent or defined parameters for PBM delivery, which may explain the limited number of ongoing clinical trials and less\u2010than\u2010optimal reported outcomes. This review outlines the associated complexities of the secondary cascade after SCI, with insights on how and when red\/near\u2010infrared irradiation may alleviate these issues. The primary focus is to discuss limitations within the field that may be inhibiting our ability to characterize optimal guidelines and specifications. Ultimately, this review provides a call for action, as there is an urgent need for consensus and standardization of therapeutic preclinical methodologies if we hope to develop treatment protocols that provide a first\u2010line minimally invasive therapy to (i) minimize injury sequelae and (ii) facilitate spinal cord repair. 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