{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:06:34Z","timestamp":1784545594680,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL062996"],"award-info":[{"award-number":["R01 HL062996"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES031087"],"award-info":[{"award-number":["R01 ES031087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM130583"],"award-info":[{"award-number":["R01GM130583"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018109","name":"Veterans Medical Research Foundation","doi-asserted-by":"publisher","award":["5I01BX000853"],"award-info":[{"award-number":["5I01BX000853"]}],"id":[{"id":"10.13039\/100018109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018109","name":"Veterans Medical Research Foundation","doi-asserted-by":"publisher","award":["I01CX002241"],"award-info":[{"award-number":["I01CX002241"]}],"id":[{"id":"10.13039\/100018109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Previous murine studies have implicated acid sphingomyelinase (aSMase)\u2010generated subcellular microvesicle particles (MVP) in photosensitivity. Objective: The current double\u2010blinded placebo\u2010controlled studies examined if a single localized ultraviolet B radiation (UVB) treatment generated more MVP in human subjects with self\u2010identified photosensitivity versus normal controls. A topical 4% formulation of the aSMase inhibitor imipramine applied immediately after UVB blocked the MVP release and erythema responses. Erythema responses at 24 and 72\u2009h in response to multiple UVB fluences and minimal erythema doses (MED) at 24\u2009h and effects of imipramine were also tested. Small cohorts of 10 adult self\u2010identified photosensitive subjects and 12 controls were enrolled in these pilot studies which revealed increased levels of skin MVP in UVB\u2010treated photosensitive subjects over controls which correlated with MED values. Moreover, post\u2010UVB application of imipramine blunted UVB\u2010induced MVP responses as well as tended to diminish erythema levels at 4\u2009h but not at 24 or 72\u2009h in photosensitive patients. Though limited by low numbers of self\u2010identified subjects, these pilot studies provide some support for the hypothesis that MVP could be involved in multiple types of human photosensitivity responses and suggest aSMase inhibition as a potential therapeutic strategy.<\/jats:p>","DOI":"10.1111\/php.70058","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:09:51Z","timestamp":1764130191000},"page":"866-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Possible involvement of keratinocyte\u2010derived microvesicle particles in human photosensitivity disorders"],"prefix":"10.1111","volume":"102","author":[{"given":"Risha","family":"Annamraju","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison S.","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Thyagarajan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle A.","family":"Corbin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0844-3207","authenticated-orcid":false,"given":"Catherine M. T.","family":"Sherwin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"},{"name":"Department of Internal Medicine The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett W.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston R.","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alycia","family":"Ketter","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aadil","family":"Umerani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-4311","authenticated-orcid":false,"given":"Craig A.","family":"Rohan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"},{"name":"Department of Dermatology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"},{"name":"The Dayton V.A. Medical Center  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-0745","authenticated-orcid":false,"given":"Michael G.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"},{"name":"The Dayton V.A. Medical Center  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn K.","family":"Crow","sequence":"additional","affiliation":[{"name":"The Compounding Lab  Huber Heights Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-1039","authenticated-orcid":false,"given":"Jeffrey B.","family":"Travers","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"},{"name":"Department of Dermatology Wright State University, Boonshoft School of Medicine  Dayton Ohio USA"},{"name":"The Dayton V.A. Medical Center  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.03.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2011.0135"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.880850"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2019_218"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800024-JLR200"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.181"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0185-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI144963"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13915"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.332395"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13247"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00331"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae078"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm070524a"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13494"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13341.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-136077"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.4.L649"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2002.00756.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030681"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822050-00005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.01.044"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1292722"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.09.008"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.70058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/php.70058","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.70058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:41:21Z","timestamp":1784544081000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.70058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/php.70058"],"URL":"https:\/\/doi.org\/10.1111\/php.70058","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}