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Growing evidence suggests that photobiomodulation is a promising treatment for rheumatoid arthritis (RA) and osteoarthritis (OA) because of its analgesic and anti\u2010inflammatory effects. However, such evidence is primarily based on studies evaluating low\u2010power laser\u2010based photobiomodulation, and few studies have assessed the efficacy of LED photobiomodulation in the treatment of RA and OA. Thus, this study aimed to review studies on LED photobiomodulation for the treatment of RA and OA, summarizing the irradiation parameters and conditions, and reporting the study types and main results. Studies on the effects of LED photobiomodulation on RA and OA were accessed via PubMed. Data from accessed studies show that LED photobiomodulation has been carried out with red and infrared LEDs based on in\u00a0vitro and in\u00a0vivo experimental models. This therapy may decrease arthritic markers, including edema, hyperalgesia, inflammation, cartilage degradation, extracellular matrix alterations, and proinflammatory cytokine levels. LED photobiomodulation could be as effective a therapy as laser photobiomodulation, but further clinical studies are necessary to verify its therapeutic benefits in both RA and OA.<\/jats:p>","DOI":"10.1111\/php.70077","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:55:06Z","timestamp":1770101706000},"page":"1079-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Light\u2010emitting diode photobiomodulation on rheumatoid arthritis and osteoarthritis: In\u00a0vitro and in\u00a0vivo studies"],"prefix":"10.1111","volume":"102","author":[{"given":"Adenilson de Souza","family":"da Fonseca","sequence":"first","affiliation":[{"name":"Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alcantara Gomes Universidade do Estado do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Instituto Biom\u00e9dico Universidade Federal do Estado do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Centro de Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio Serra dos \u00d3rg\u00e3os  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via","family":"de Paoli","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8pp00176f"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1753706"},{"key":"e_1_2_9_4_1","first-page":"39","article-title":"Light\u2010emitting diodes: a brief review of uses, innovations, and dynamics","volume":"8","author":"Opel DR","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_5_1","article-title":"The hypothesis that cytochrome c oxidase is the primary chromophore responsible for the effects of phototherapy","volume":"3","author":"Rich PR","year":"2022","journal-title":"Front Photonics"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.16.97"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","unstructured":"WhelanHT HouleJM DonohoeDL et\u00a0al.Medical applications of space light\u2010emitting diode technology \u2013 Space station and beyond.1999. 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