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The lack of development of resistance against this therapy makes it indicated even for the treatment of fungi resistant to antifungals. There are numerous in\u00a0vitro studies that demonstrate the benefits of aPDT on pathogenic fungi with a high mortality rate, such as those of the genus\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. However, studies show variations in the parameters used in their protocols, which makes it difficult to identify a more effective protocol for advancing studies in animal models. 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