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In this study, a series of substituted chalcones inspired by the chemical structure of avobenzone (AVO) was synthesized and systematically evaluated for UV absorption profiles, photostability, antioxidant potential, photoprotection, and safety\u2010related properties. Among the compounds, the 2\u2010hydroxychalcones\n                    <jats:bold>3ca<\/jats:bold>\n                    and\n                    <jats:bold>3cb<\/jats:bold>\n                    showed the most promising profiles. Chalcone\n                    <jats:bold>3ca<\/jats:bold>\n                    exhibited\n                    <jats:italic>\u03bb<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    at 365\u2009nm, critical wavelength of 386\u2009nm, UVA\/UVB ratio of 6.3, and molar absorptivity of 58,880\u2009M\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    , whereas\n                    <jats:bold>3cb<\/jats:bold>\n                    showed\n                    <jats:italic>\u03bb<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    at 353\u2009nm, critical wavelength of 376\u2009nm, UVA\/UVB ratio of 3.2, and molar absorptivity of 28,900\u2009M\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Both compounds fulfilled broad\u2010spectrum protection criteria and showed &lt;5% degradation after UVA and UVB irradiation, with photostability comparable to benzophenone\u20103 and superior to AVO. Formulations containing\n                    <jats:bold>3ca<\/jats:bold>\n                    and\n                    <jats:bold>3cb<\/jats:bold>\n                    reduced UVA\u2010induced DNA damage by 90.4% and 95.1%, respectively. Skin permeation studies demonstrated predominant retention in the stratum corneum (94.1% for\n                    <jats:bold>3ca<\/jats:bold>\n                    and 97.4% for\n                    <jats:bold>3cb<\/jats:bold>\n                    ), minimal penetration into viable epidermis and dermis, and no detectable compound in receptor fluid. Both chalcones showed no relevant irritation in the HET\u2013CAM assay and no significant alterations in skin biometric parameters after topical application. Collectively, these findings support the potential of hydroxy\u2010substituted chalcones as photostable broad\u2010spectrum UV filters for topical application.\n                  <\/jats:p>","DOI":"10.1111\/php.70119","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:44:34Z","timestamp":1780123474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of chalcones structure\u2010related to avobenzone: Photoprotection, photostability, and safety evaluation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-0197","authenticated-orcid":false,"given":"Gabriela Zanella","family":"Marcon","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Graduate Program Federal University of Santa Maria (UFSM)  Santa Maria 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