{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:48:20Z","timestamp":1782820100836,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp;amp; Photobiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Skin cancer remains one of the most prevalent malignancies worldwide, with increasing incidence rates for both melanoma and non\u2010melanoma subtypes. In this context, nanotechnology\u2010based phototherapies have emerged as promising therapeutic strategies. This systematic review aimed to analyze the therapeutic potential of metallic nanoparticles (MNPs) for photodynamic therapy (PDT) and photothermal therapy (PTT) in skin cancer treatment. Three databases were consulted\u2014Scopus, Web of Science, and PubMed; the studies were transferred to the Zotero software, where they were analyzed by the authors according to the predefined inclusion and exclusion criteria. Most of the studies found focus on melanoma. In\u00a0vitro findings demonstrated significant reductions in cell viability following combined MNPs and near\u2010infrared (NIR) irradiation, predominantly mediated by apoptosis and associated with increased reactive oxygen species (ROS) levels and temperature elevation (\u25b3\n                    <jats:italic>T<\/jats:italic>\n                    ). In\u00a0vivo studies confirmed enhanced tumor suppression with combined therapy compared to isolated treatments. Although temperature increments were lower in\u00a0vivo than in\u00a0vitro, therapeutic efficacy remained significant. Safety assessments indicated no relevant changes in body weight or histopathological alterations in major organs, suggesting low systemic toxicity. Collectively, ROS generation and photothermally induced hyperthermia represent key mechanisms driving tumor regression. Therefore, MNPs thus emerge as promising and biocompatible photoactive agents for skin cancer treatment with NIR association.\n                  <\/jats:p>","DOI":"10.1111\/php.70129","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:19:34Z","timestamp":1782818374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phototherapies mediated by metallic nanoparticles and near\u2010infrared radiation in skin cancer: A systematic review"],"prefix":"10.1111","author":[{"given":"Tamyris","family":"Devincenzi","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Fisiol\u00f3gicas, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal do Rio Grande \u2013 FURG  Rio Grande Brazil"},{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal do Rio Grande \u2013 FURG  Rio Grande 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