{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:53:54Z","timestamp":1782820434512,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["Fiscal year 2025"],"award-info":[{"award-number":["Fiscal year 2025"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    surface alterations following photodynamic therapy using Raman spectroscopy were studied. Previously effective photosensitizers were tested: 200\u2009\u03bcM erythrosine, 100\u2009mM KI, 200\u2009\u03bcM erythrosine+100\u2009mM KI irradiated with a 530\u2009\u00b1\u200910\u2009nm LED (250\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 20\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    per session for two sessions (total fluence: 40\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    )), 60\u2009M bisdemethoxycurcumin irradiated with a 430\u2013480\u2009nm LED (950\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 75\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ), 100\u2009\u03bcM melatonin irradiated with a 630\u2009\u00b1\u200910\u2009nm LED (250\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 75\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ), and 60\u2009\u03bcM bisdemethoxycurcumin+100\u2009\u03bcM melatonin with dual light. Treatments were applied to mature\n                    <jats:italic>C. albicans<\/jats:italic>\n                    biofilms. Negative and positive controls were phosphate\u2010buffered saline and nystatin, respectively. Raman spectroscopy used a 50\u00d7 objective lens, 600 lines\/mm grating, and 785\u2009nm laser. Data were analyzed using principal component analysis. Erythrosine and erythrosine+KI induced specific surface alterations with Raman peaks similar to nystatin and differing from the negative control at 625, 1159, 1270, 1336, 1491, and 1603\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    .Raman peaks at 625\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    correspond to phenylalanine, 1159\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    to carbohydrate, 1270\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    to amide III, 1336\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    to proteins and carbohydrate, 1491\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    to nucleic acid bases, and 1603\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    to ergosterol. Other treatment groups showed no differences from the negative control. Erythrosine and erythrosine+KI exhibited similar mechanistic cell surface alterations to nystatin.\n                  <\/jats:p>","DOI":"10.1111\/php.70132","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:37:40Z","timestamp":1782819460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surface alteration of\n                    <i>Candida albicans<\/i>\n                    after antifungal photodynamic therapy: A Raman spectroscopic study"],"prefix":"10.1111","author":[{"given":"Phuriphat","family":"Techalapha","sequence":"first","affiliation":[{"name":"Division of Oral Diagnosis, Department of Oral Biomedical Sciences, Faculty of Dentistry Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iyadara","family":"Ngamwatana","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnosis, Department of Oral Biomedical Sciences, Faculty of Dentistry Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laksika","family":"Boonwittaya","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnosis, Department of Oral Biomedical Sciences, Faculty of Dentistry Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-6716","authenticated-orcid":false,"given":"Prapassara","family":"Sirikarn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Public Health Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4795-6221","authenticated-orcid":false,"given":"Teerasak","family":"Damrongrungruang","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnosis, Department of Oral Biomedical Sciences, Faculty of Dentistry Khon Kaen University  Khon Kaen Thailand"},{"name":"Melatonin Research Program Khon Kaen University  Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10123-018-0014-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.408"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040613"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB01108F"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.01.187"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123190"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911373"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2024.2369357"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74315-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00202"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.683580"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c00817"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"45","article-title":"Use 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