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We report the design and synthesis of a novel CRT\u2010targeting trisaccharide (\u03b1\u2010\n                    <jats:sc>D<\/jats:sc>\n                    \u2010Glc\n                    <jats:italic>p<\/jats:italic>\n                    \u2010(1\u2009\u2192\u20093)\u2010\u03b1\u2010\n                    <jats:sc>D<\/jats:sc>\n                    \u2010Man\n                    <jats:italic>p<\/jats:italic>\n                    \u2010(1\u2009\u2192\u20092)\u2010Man, G1M2), G1M2\u2010EG8\u2010ZnChl, in which a CRT\u2010recognizing trisaccharide is covalently linked to a zinc chlorophyll derivative (ZnChl) as a photosensitizer through an oligoethylene glycol spacer. The conjugate exhibited characteristic chlorin absorption bands at approximately 434 and 666\u2009nm in aqueous buffer, enabling excitation in the red\u2010light region. Upon light irradiation, singlet oxygen generation was confirmed using 1,3\u2010diphenylisobenzofuran as a chemical quencher in ethanol, and the singlet oxygen quantum yield was determined to be\n                    <jats:italic>\u03a6<\/jats:italic>\n                    <jats:sub>\u0394<\/jats:sub>\n                    \u2009=\u20090.26. The complex showed negligible photodegradation under the irradiation for 80\u2009s, indicating sufficient photostability of the chlorin core in G1M2\u2010EG8\u2010ZnChl. Binding assays demonstrated that G1M2\u2010EG8\u2010ZnChl interacted with human CRT through its glycan recognition domain and aglycon recognition domain. Although further biological investigations are required to elucidate cellular interactions and functional outcomes, this work demonstrates a molecular design strategy for integrating CRT\u2010recognition motifs with photosensitizers while retaining essential photophysical and photochemical properties.\n                  <\/jats:p>","DOI":"10.1111\/php.70134","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:43:24Z","timestamp":1783745004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calreticulin\u2010targeting trisaccharide Glc\u2010Man\u2010Man conjugated with zinc chlorophyll derivative as a potential photosensitizer"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-4544","authenticated-orcid":false,"given":"Mitsuaki","family":"Hirose","sequence":"first","affiliation":[{"name":"Department of Science and Technology Seikei University  Tokyo 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Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4523-3945","authenticated-orcid":false,"given":"Taiki","family":"Kuribara","sequence":"additional","affiliation":[{"name":"Department of Glyco\u2010Oncology and Medical Biochemistry, Research Center Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4957-1686","authenticated-orcid":false,"given":"Kiichiro","family":"Totani","sequence":"additional","affiliation":[{"name":"Department of Science and Technology Seikei University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1042\/BJ20081847","article-title":"Calreticulin, a multi\u2010process calcium\u2010buffering chaperone of the endoplasmic 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