{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T07:43:05Z","timestamp":1786174985565,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance code 001"],"award-info":[{"award-number":["Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp;amp; Photobiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ultraviolet (UV) radiation exerts a strong influence on skin homeostasis and directly affects communication between keratinocytes and melanocytes. This study investigated how exposure of keratinocytes to UVA and UVB radiation alters cellular signaling with melanocytes using conditioned medium, that is, culture medium collected from keratinocytes after irradiation, to evaluate its effects on mitochondrial activity, proliferation, viability, and cell cycle progression of melanocytes. Keratinocytes were irradiated with UVA (4\u2009J.cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) or UVB (20\u2009mJ.cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ), and the conditioned medium was collected 24\u2009h after irradiation. Subsequently, irradiated or non\u2010irradiated melanocytes were treated with the medium. The results showed that the conditioned medium from keratinocytes, especially those exposed to UVA radiation, significantly increased mitochondrial activity and melanocyte proliferation. Although direct UVA exposure reduced melanocyte viability, treatment with conditioned medium promoted cellular recovery over time. The conditioned medium obtained from UVB\u2010irradiated keratinocytes also stimulated proliferation, although to a lesser extent than the medium from non\u2010irradiated keratinocytes. Additionally, it was observed that the conditioned medium from UVA\u2010irradiated keratinocytes induced cell cycle progression, increasing the proportion of melanocytes in the S and G2\/M phases. These findings indicate that soluble factors secreted by irradiated keratinocytes play an important role in modulating the functional responses of melanocytes, potentially contributing to adaptive mechanisms related to UV radiation exposure.\n                  <\/jats:p>","DOI":"10.1111\/php.70143","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:51:35Z","timestamp":1786171895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Keratinocytes exposed to ultraviolet A and ultraviolet B radiation induce responses in melanocytes"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2181-7361","authenticated-orcid":false,"given":"Lais","family":"Zort\u00e9a","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Cultura Celular Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o Em Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-1438","authenticated-orcid":false,"given":"Andressa Mai","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura Celular Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o Em Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3752-860X","authenticated-orcid":false,"given":"Alessandra Costa","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura Celular Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o Em Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9131-4729","authenticated-orcid":false,"given":"Eduardo Felipe","family":"Wagner","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura Celular Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o Em Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8744-9240","authenticated-orcid":false,"given":"Tanira","family":"da Silveira Prieto","sequence":"additional","affiliation":[{"name":"Universidade Federal Do Pampa \u2013 UNIPAMPA  RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-6204","authenticated-orcid":false,"given":"Andr\u00e9s Delgado","family":"Ca\u00f1edo","sequence":"additional","affiliation":[{"name":"Universidade Federal Do Pampa \u2013 UNIPAMPA  RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-5584","authenticated-orcid":false,"given":"Daza de Moraes Vaz Batista","family":"Filgueira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura Celular Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal Do Rio Grande \u2013 FURG  RS Brazil"},{"name":"Programa de 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