{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:40:36Z","timestamp":1792568436932,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tendon injuries are challenging to treat due to limited intrinsic healing, and although photobiomodulation (PBM) and platelet\u2010rich plasma (PRP) show therapeutic potential, their combined effects remain unclear. This study evaluated the individual and combined efficacy of PBM and PRP on Achilles tendon repair in rats. A total of 144 rats were assigned to six groups and treated with PBM, PRP, or combined PBM\u2009+\u2009PRP therapy; tissues were collected at 1 and 8\u2009weeks for biochemical and histological assessment. Both PBM and PRP reduced IL\u20101\u03b2 and TNF\u2010\u03b1 levels and improved collagen organization, while the combined therapy produced the most pronounced anti\u2010inflammatory response and structural recovery. Notably, PBM\u2009+\u2009PRP significantly enhanced and prolonged PDGF\u2010BB expression compared with either treatment alone. These findings demonstrate that PBM and PRP each promote tendon healing, but their combination yields superior therapeutic benefits through amplified modulation of inflammatory and regenerative pathways, highlighting their potential as an improved therapeutic strategy.<\/jats:p>","DOI":"10.1111\/php.70169","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:02:26Z","timestamp":1792566146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined effects of photobiomodulation and platelet\u2010rich plasma on healing of acute Achilles tendon injuries in rats"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8091-896X","authenticated-orcid":false,"given":"Hao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Pain Medicine, Nanjing Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing 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