{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:41:29Z","timestamp":1779234089068,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n The success rates of conventional treatments to acne vulgaris are limited because of intolerance and resistance. Photodynamic therapy with topical 5\u2010aminolevulinic acid (\n ALA<\/jats:styled-content>\n ) and red light has been introduced. However, the side effects especially pigmentation are common.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To study the efficacy and safety of\n ALA<\/jats:styled-content>\n \u2010photodynamic therapy (\n PDT<\/jats:styled-content>\n ) with 420\u2013950\u2009nm intense pulsed light (\n IPL<\/jats:styled-content>\n ) in\n C<\/jats:styled-content>\n hinese patients with acne vulgaris.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty\u2010one patients with moderate to severe facial acne were randomly assigned to\n ALA\u2010IPL\u2010PDT<\/jats:styled-content>\n group and\n IPL<\/jats:styled-content>\n group. Ten percent topical\n ALA<\/jats:styled-content>\n was applied to patients in the\n ALA\u2010IPL\u2010PDT<\/jats:styled-content>\n group, while placeboes were applied to patients in the\n IPL<\/jats:styled-content>\n group. After 1\u2009h occlusion, all patients were illuminated with 420\u2013950\u2009nm\n IPL<\/jats:styled-content>\n . The patients in both groups had four treatment sessions with 1\u2010week intervals. One week after each treatment and 4, 8, and 12 weeks after four sessions, acne lesion counts and adverse events were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twelve weeks after treatments, mean reductions of global lesion counts of\n ALA\u2010IPL\u2010PDT<\/jats:styled-content>\n group and\n IPL<\/jats:styled-content>\n group were 75.2% and 51.0%, respectively. Mean reductions of inflammatory and non\u2010inflammatory lesion counts in\n ALA\u2010IPL\u2010PDT<\/jats:styled-content>\n group were (83.6\u2009\u00b1\u20094.1)% and (57.5\u2009\u00b1\u20096.8)%, respectively. No severe adverse events were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n ALA\u2010IPL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n is an effective treatment for moderate to severe acne vulgaris, and side effects are mild and reversible.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/phpp.12031","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T06:33:22Z","timestamp":1362465202000},"page":"90-96","source":"Crossref","is-referenced-by-count":52,"title":["Effectiveness of photodynamic therapy with topical 5\u2010aminolevulinic acid and intense pulsed light in\n C<\/scp>\n hinese acne vulgaris patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Xingyu","family":"Mei","sequence":"first","affiliation":[{"name":"Dermatology Department Shanghai First People's Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Shi","sequence":"additional","affiliation":[{"name":"Dermatology Department Shanghai First People's Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinglan","family":"Piao","sequence":"additional","affiliation":[{"name":"Dermatology Department Tongji Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00612.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1614.2003.01111.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017869"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.9.1093"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04086.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06110.x"},{"issue":"8","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1097\/00042728-200508000-00004","article-title":"Effectiveness of photodynamic therapy with topical 5\u2010aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: 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