{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:29:20Z","timestamp":1780568960139,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>This meta\u2010analysis was designed to assess the efficacy of topical 5\u2010aminolaevulinic acid (ALA<\/jats:styled-content>) photodynamic therapy (PDT<\/jats:styled-content>) in C<\/jats:styled-content>hinese patients with condylomata acuminata (CA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Electronic literature databases (M<\/jats:styled-content>edline, E<\/jats:styled-content>mbase, C<\/jats:styled-content>ochrane L<\/jats:styled-content>ibrary, C<\/jats:styled-content>hina N<\/jats:styled-content>ational K<\/jats:styled-content>nowledge I<\/jats:styled-content>nfrastructure, and W<\/jats:styled-content>anfang database) were searched for relevant randomized controlled trials (RCTs<\/jats:styled-content>) published prior to O<\/jats:styled-content>ctober 2012. Only RCTs<\/jats:styled-content> that compared ALA\u2010PDT<\/jats:styled-content> to non\u2010ALA<\/jats:styled-content>\u2010PDT<\/jats:styled-content> for patients with genital condylomata were selected. The outcomes included the recurrence rate and adverse events. The risk ratios (RRs<\/jats:styled-content>) and 95% confidence intervals (CIs<\/jats:styled-content>) were calculated as the ALA\u2010PDT<\/jats:styled-content> vs. without ALA\u2010PDT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty RCTs<\/jats:styled-content> composed of 1903 patients (ALA\u2010PDT<\/jats:styled-content>, n\u2009=\u20091106; non\u2010ALA<\/jats:styled-content>\u2010PDT<\/jats:styled-content>, n\u2009=\u2009797) were included in the meta\u2010analysis. ALA\u2010PDT<\/jats:styled-content> decreased the recurrence rate within 12 week after treatment (vs. without ALA\u2010PDT<\/jats:styled-content>, RR<\/jats:styled-content>: 0.28, 95% CI<\/jats:styled-content>: 0.22\u20130.35) and 24 week after treatment (vs. without ALA\u2010PDT<\/jats:styled-content>, RR<\/jats:styled-content>: 0.24, 95% CI<\/jats:styled-content>: 0.17\u20130.34) in a fixed\u2010effect model. The common adverse events related ALA\u2010PDT included a mild burning and\/or stinging sensation, erythema, mild edema, erosion, and hyperpigmentation.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Local application of ALA\u2010PDT<\/jats:styled-content> reduced recurrence rate vs. without ALA\u2010PDT<\/jats:styled-content>. The use of ALA<\/jats:styled-content>\u2010PDT<\/jats:styled-content> should be considered as a feasible therapy for the treatment of CA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12043","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T10:04:54Z","timestamp":1368525894000},"page":"149-159","source":"Crossref","is-referenced-by-count":44,"title":["5\u2010aminolevulinic acid\u2010based photodynamic therapy for the treatment of condylomata acuminata in C<\/scp>hinese patients: a meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Zuolin","family":"Ying","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shanghai First People's Hospital School of Medicine, Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai First People's 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