{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:15:20Z","timestamp":1791324920000,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Acne conglobata is hardly curable and easily leads to scar formation after treatment using traditional methods.<\/jats:p><\/jats:sec>Aim<\/jats:title>To develop a novel way to treat acne conglobata.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010five patients with facial acne conglobata were included in this clinical study and divided into either a treatment group (n<\/jats:italic>\u2009=\u200935) to receive photodynamic therapy (PDT<\/jats:styled-content>) with topical 5% 5\u2010aminolevulinic acid and red light once every 10 days for a month or a control group (n<\/jats:italic>\u2009=\u200940) to receive a C<\/jats:styled-content>hinese herbal medicine mask plus red light once per week for the same duration. Patients in both groups were given oral viaminate capsules, doxycycline, zinc gluconate, and topical metronidazole. Efficacy was evaluated with respect to symptom score, cure rate, and response rate up to 2 weeks following the final treatment, and time points for assessment included baseline (D<\/jats:styled-content>0<\/jats:sub>), the visit before each treatment (D<\/jats:styled-content>10<\/jats:sub> and D<\/jats:styled-content>20<\/jats:sub> for the treatment group, and D<\/jats:styled-content>7<\/jats:sub>, D<\/jats:styled-content>14<\/jats:sub>, and D<\/jats:styled-content>21<\/jats:sub> for the control group), and 2 weeks after treatment (D<\/jats:styled-content>34<\/jats:sub> for the treatment group and D<\/jats:styled-content>35<\/jats:sub> for the control group). Safety was assessed by recording adverse effects.<\/jats:p><\/jats:sec>Results<\/jats:title>Treatment with PDT<\/jats:styled-content> significantly improved acne lesions and reduced scar formation. The treatment group had a significantly lower symptom score, a higher cure rate, and response rate than the control group. No systemic side effects occurred.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The treatment of acne conglobata with PDT<\/jats:styled-content> is associated with a high cure rate, short treatment period, few side effects, and reduced scar formation. To the best of our knowledge, this is the first report on the treatment of acne conglobata with PDT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12059","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T04:19:32Z","timestamp":1378268372000},"page":"233-238","source":"Crossref","is-referenced-by-count":28,"title":["Short\u2010term clinical effects of photodynamic therapy with topical 5\u2010aminolevulinic acid for facial acne conglobata: an open, prospective, parallel\u2010arm trial"],"prefix":"10.1111","volume":"29","author":[{"given":"Gui\u2010Lan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Feng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Qin","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Rui","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lanzhou General Hospital of Lanzhou Military Area Command Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70442-6"},{"key":"e_1_2_5_3_1","unstructured":"DavisMG.The treatment of cystic acne.2012. 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