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Various treatment modalities have been recommended for the management of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>, but only a few studies exist regarding the efficacy of bath <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> photochemotherapy in the treatment of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of bath <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> photochemotherapy in the management of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> in a retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight patients (23 women and five men) with a diagnosis of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>, confirmed by histology, were included in the study. Patients were treated with a thrice\u2010weekly regimen of bath immersion in 0.2\u2009mg\/1 water solution of 8\u2010methoxypsoralen, followed by irradiation with <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven patients (39%) showed complete remission (complete softening of the sclerotic plaques with or without postinflammatory hyper\u2010 or hypopigmentation) after a mean of 71 treatments (range 33\u2013170) and a mean cumulative dose of 115\u2009J\/cm<jats:sup>2<\/jats:sup> (range 11\u2013232). Partial softening and regression of the sclerotic plaques was observed in 14 patients (50%). Three patients (10.7%) showed no effect, and in none of the patients was worsening noted during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our experience, bath <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> photochemotherapy is an effective and well\u2010tolerated treatment option for <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> and should be considered as one of the first\u2010line treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12063","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T04:19:32Z","timestamp":1378268372000},"page":"247-252","source":"Crossref","is-referenced-by-count":19,"title":["Bath psoralen\u2013<scp>UVA<\/scp> photochemotherapy for localized scleroderma: experience from a single 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