{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:45:05Z","timestamp":1790671505964,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Acne vulgaris is common in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian populations. We compared three methods of phototherapy for the treatment of moderate to severe facial acne vulgaris in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomly assigned to receive photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>), intense pulsed light (<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>) or blue\u2013red light\u2010emitting diode (<jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content>) phototherapy to the right side of the face until the inflammatory lesion count reduced by \u2265\u200990%. Patients were examined at 1 and 3 months after the final treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 150 patients (92 males; mean age, 28 years). At 1 month, \u226590% clearance or moderate improvement occurred in 46\/50 (92%), 29\/50 (58%) and 22\/50 (44%) patients in the <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content> groups, respectively (mean number of sessions required, <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>: 3\u2009\u00b1\u20091.52; <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>: 6\u2009\u00b1\u20092.15; <jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content>: 9\u2009\u00b1\u20093.34). Forty\u2010six (92%) patients experienced mild to moderate pain, erythema and edema after <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, which resolved within 5\u20137 days. Slight erythema and stinging were reported immediately after <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content>, resolving within 2\u2009h. After 3 months, minimal papules and pustules were observed in 4 patients in the <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> group, 7 in the <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content> group and 12 in the <jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content> group, but no nodular pustules recurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Phototherapy is efficacious for moderate to severe facial acne vulgaris.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12098","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T10:58:43Z","timestamp":1386586723000},"page":"246-253","source":"Crossref","is-referenced-by-count":45,"title":["Randomized trial of three phototherapy methods for the treatment of acne vulgaris in <scp>C<\/scp>hinese patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Li\u2010Hong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology General Hospital of Beijing Military Region of PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Beijing Military Region of PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Xi","family":"An","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Beijing Military Region of PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Beijing Military Region of PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Beijing Military Region of PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Ya","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Beijing Military Region of PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01154-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051726"},{"key":"e_1_2_6_4_1","first-page":"4","article-title":"Physiopathology of acne vulgaris: recent data, new understanding of the treatments","volume":"14","author":"Pawin H","year":"2004","journal-title":"Eur J 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