{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:57:36Z","timestamp":1774875456086,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>It is widely believed that an imbalance between activated CD<\/jats:styled-content>8+<\/jats:sup>T<\/jats:styled-content> cells and regulatory T<\/jats:styled-content> cells (T<\/jats:styled-content>regs) exists in patients with vitiligo. Although there is evidence that narrow band ultraviolet (NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>) irradiation can induce T<\/jats:styled-content>regs' number and activity, but up to our knowledge, none of the published studies involved the possible effect of NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> on T<\/jats:styled-content>regs in vitiligo.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate the effect of NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> on circulating CD<\/jats:styled-content>4+<\/jats:sup>CD<\/jats:styled-content>25high<\/jats:sup>F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup>regulatory T<\/jats:styled-content> cells (F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup>T<\/jats:styled-content>regs) in vitiligo.<\/jats:p><\/jats:sec>Methods<\/jats:title>This prospective analytic study included 20 patients with active non\u2010segmental vitiligo and 20 healthy controls. The patients were exposed to NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> therapy three times per week for 30 sessions. Blood sampling before and after NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> phototherapy was done to evaluate circulating CD<\/jats:styled-content>4+<\/jats:sup>CD<\/jats:styled-content>25high<\/jats:sup>T<\/jats:styled-content>regs and F<\/jats:styled-content>oxp3+<\/jats:sup>T<\/jats:styled-content>regs.<\/jats:p><\/jats:sec>Results<\/jats:title>The CD<\/jats:styled-content>4+<\/jats:sup>CD<\/jats:styled-content>25high<\/jats:sup>T<\/jats:styled-content>regs% and F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup>T<\/jats:styled-content>regs% were significantly higher in vitiligo patients compared with controls. NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> therapy decreased both of them in patients, but they did not reach those of controls. Each of circulating CD<\/jats:styled-content>4+<\/jats:sup>CD<\/jats:styled-content>25high<\/jats:sup>T<\/jats:styled-content>regs% and F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup>T<\/jats:styled-content>regs% didn't correlate with either extent or activity of vitiligo before or after NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>T<\/jats:styled-content>regs functional defect is probably having an impact on NSV<\/jats:styled-content>. NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> may improve the function of T<\/jats:styled-content>regs. Understanding the mechanisms through which NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> exert its effect on reducing the number of circulating T<\/jats:styled-content>regs would help open up the paths for future therapeutic options.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12104","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T09:50:31Z","timestamp":1387792231000},"page":"254-261","source":"Crossref","is-referenced-by-count":29,"title":["Effect of narrow band\u2010ultraviolet B<\/scp> on CD<\/scp>4+<\/sup>CD<\/scp>25high<\/sup>F<\/scp>oxP<\/scp>3+<\/sup>T<\/scp>\u2010lymphocytes in the peripheral blood of vitiligo patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Nayera H.","family":"Moftah","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine for Girls, Al Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha A. 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