{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:32:23Z","timestamp":1789381943516,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Isotretinoin has been used in combination with oral psoralen\u2009+\u2009UVA (PUVA<\/jats:styled-content>) and narrowband UVB (NBUVB<\/jats:styled-content>) for treating psoriasis, especially in women of child\u2010bearing age. The efficacy of oral psoralen\u2009+\u2009sun exposure (PUVA<\/jats:styled-content>sol) is comparable to that of PUVA<\/jats:styled-content>. This study was planned to compare the efficacy of oral PUVA<\/jats:styled-content>sol with that of the combination of oral isotretinoin and PUVA<\/jats:styled-content>sol in patients with chronic plaque psoriasis.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty patients with psoriasis vulgaris were randomized to two groups. Group A<\/jats:styled-content> (control group) received PUVA<\/jats:styled-content>sol only. Group B<\/jats:styled-content> (intervention group) received PUVA<\/jats:styled-content>sol\u2009+\u2009isotretinoin (0.5\u2009mg\/kg\/day). P<\/jats:styled-content>soriasis A<\/jats:styled-content>rea S<\/jats:styled-content>everity I<\/jats:styled-content>ndex (PASI<\/jats:styled-content>) score was recorded at baseline and weeks 4, 8 and 12. Dermatology Life Quality Index was assessed at baseline and 12 weeks. The end point of the study was PASI<\/jats:styled-content> 75 or 12 weeks, whichever came earlier.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010five patients completed the study. There were statistically significant differences between the two study groups for the number of patients achieving the endpoint of PASI<\/jats:styled-content> 75, PASI<\/jats:styled-content> scores at the end of 12 weeks, mean duration to achieve PASI<\/jats:styled-content> 75, number of PUVA<\/jats:styled-content>sol sessions needed to achieve PASI<\/jats:styled-content>75 and mean cumulative dosage of 8\u2010methoxypsoralen needed to achieve PASI<\/jats:styled-content> 75.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The combination of isotretinoin with PUVA<\/jats:styled-content>sol is more effective compared with PUVA<\/jats:styled-content>sol alone for treating chronic plaque psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12125","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T07:57:06Z","timestamp":1400140626000},"page":"294-301","source":"Crossref","is-referenced-by-count":16,"title":["Clinical efficacy of psoralen\u2009+\u2009sunlight vs. combination of isotretinoin and psoralen\u2009+\u2009sunlight for the treatment of chronic plaque\u2010type psoriasis vulgaris: a randomized hospital\u2010based study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-6871","authenticated-orcid":false,"given":"Pratik","family":"Gahalaut","sequence":"first","affiliation":[{"name":"Department of Dermatology Sri Ram Murti Smarak Institute of Medical Sciences Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet Singh","family":"Soodan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sri Ram Murti Smarak Institute of Medical Sciences Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sri Ram Murti Smarak Institute of Medical Sciences Bareilly 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