{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:26:01Z","timestamp":1791487561995,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Frequent topical antiseptic use to hands is now common in healthcare and other work environments. Inevitably, the use of such antiseptics will present an occupational risk for irritancy and allergic dermatitis. New, less irritant and even non\u2010chemical antimicrobial approaches are under investigation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A Sterilray disinfectant source (222\u2009nm) conventionally used to sterilize equipment and work surfaces was assessed for tolerability in human skin. Using an escalating dosage study methodology, four skin phototype I and II healthy volunteers had their minimal erythema dose (\n MED<\/jats:styled-content>\n ) determined. Punch biopsies of irradiated sites were stained for cyclobutane pyrimidine dimers (\n CPD<\/jats:styled-content>\n ). The degree of\n CPD<\/jats:styled-content>\n was compared with that in biopsies from unexposed skin and from areas exposed to\n UVB<\/jats:styled-content>\n (280\u2013315\u2009nm) radiation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Calibrated spectral measurements revealed emission at a peak wavelength of 222\u2009nm with 97% emission at wavelengths less than 250\u2009nm. At low doses below the threshold bacteriostatic effect, the source was capable of inducing both erythema and\n CPD<\/jats:styled-content>\n formation in human skin. In two individuals, cells in the basal layer were not shielded by the overlying tissue as indicated by the presence of CPD.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The source showed an erythemogenic or\n CPD<\/jats:styled-content>\n potential at lower doses than those required to reach the reported threshold bacteriostatic effect.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/phpp.12156","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T07:22:42Z","timestamp":1418368962000},"page":"159-166","source":"Crossref","is-referenced-by-count":54,"title":["The effect of 222\u2010nm\n UVC<\/scp>\n phototesting on healthy volunteer skin: a pilot study"],"prefix":"10.1111","volume":"31","author":[{"given":"Julie A","family":"Woods","sequence":"first","affiliation":[{"name":"Photobiology Unit Ninewells Hospital & Medical School University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Histopathology Ninewells Hospital & Medical School Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Donald","family":"Forbes","sequence":"additional","affiliation":[{"name":"Toxarus Inc. Malvern PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Coates","sequence":"additional","affiliation":[{"name":"Tayside Tissue Bank Ninewells Hospital & Medical School University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Gardner","sequence":"additional","affiliation":[{"name":"Photobiology Unit Ninewells Hospital & Medical School University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan M","family":"Valentine","sequence":"additional","affiliation":[{"name":"Photobiology Unit Ninewells Hospital & Medical School University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally H","family":"Ibbotson","sequence":"additional","affiliation":[{"name":"Photobiology Unit Ninewells Hospital & Medical School University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Spectratox Ltd. c\/o Photobiology Unit Ninewells Hospital & Medical School University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fricker","sequence":"additional","affiliation":[{"name":"GoJo Industries 1 GOJO Plaza Akron OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Moseley","sequence":"additional","affiliation":[{"name":"Photobiology Unit Ninewells Hospital & Medical School University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2011.00886.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/503643"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00436.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.08.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2012.0366"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31825c149c"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00161-12"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3pp25408a"},{"key":"e_1_2_7_10_1","first-page":"285","article-title":"The multilayered organization of engineered human skin does not influence the formation of sunlight\u2010induced cyclobutane pyrimidine dimers in cellular DNA","volume":"59","author":"Therrien JP","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1966.189"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00391.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12457"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1562\/2005-10-27-RA-728"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076968"}],"container-title":["Photodermatology, Photoimmunology & Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphpp.12156","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:28:13Z","timestamp":1695500893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/phpp.12156"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12156","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}