{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:11:33Z","timestamp":1696155093228},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Ultraviolet A (UVA<\/jats:styled-content>) irradiation before allergic sensitization induces immunosuppression, but the precise mechanism remained unclear. In this study, we examined the influence of UVA<\/jats:styled-content> irradiation of the eye on contact hypersensitivity (CHS<\/jats:styled-content>) and the role of mast cells in CHS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We used two types of haptens, fluorescein isothiocyanate (FITC<\/jats:styled-content>: a T<\/jats:styled-content>h2 type hapten) and 4\u2010ethoxymethylene\u20102\u2010phenyl\u20102\u2010oxazolin\u20105\u2010one (oxazolone: a T<\/jats:styled-content>h1 type hapten). A 300\u2009kJ\/m2<\/jats:sup> dose of UVA<\/jats:styled-content> irradiation was delivered to the eyes. After UVA<\/jats:styled-content> irradiation, we sensitized abdominal shaved skin and challenged the ear epidermis and colons of these mice with each hapten.<\/jats:p><\/jats:sec>Results<\/jats:title>After UVA<\/jats:styled-content> irradiation, the CHS<\/jats:styled-content> of the skin and colon were not inhibited in the FITC<\/jats:styled-content>\u2010sensitized mice. However, in the oxazolone\u2010sensitized mice, only the CHS<\/jats:styled-content> of the skin was inhibited by UVA<\/jats:styled-content> irradiation. The inflammation of the colon became more severe after UVA<\/jats:styled-content> irradiation. In mast cell\u2013deficient (W<\/jats:styled-content>\/W<\/jats:styled-content>v) mice sensitized to FITC<\/jats:styled-content>, the CHS<\/jats:styled-content> was weaker than that in WT<\/jats:styled-content> mice. Moreover, the reduction of immunosuppression in ear swelling was seen for one of the two models they used.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These results suggest that the mast cells induced by UVA<\/jats:styled-content> irradiation of the eye have different roles in the epidermis and colon and have different responses to different haptens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12157","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T01:53:58Z","timestamp":1418608438000},"page":"129-140","source":"Crossref","is-referenced-by-count":4,"title":["UVA<\/scp> irradiation of the eye modulates the contact hypersensitivity of the skin and intestines by affecting mast cells in mice"],"prefix":"10.1111","volume":"31","author":[{"given":"Yurika","family":"Yamate","sequence":"first","affiliation":[{"name":"Department of Physiology Osaka City University Graduate School of Medicine Osaka Japan"},{"name":"Department of Pharmaceutical Science 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