{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:43:27Z","timestamp":1779097407092,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photodynamic therapy with 5\u2010methyl\u2010aminolevulinate and photodynamic therapy with trichloroacetic acid 50% are the two techniques utilized in the management of actinic keratosis. This study was planned to compare the efficacy, adverse effects, recurrence and cosmetic outcome of these option therapies in patients with multiple actinic keratosis of the scalp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen patients with multiple actinic keratosis were treated with one of the two treatments on half of the scalp at baseline, while the other treatment was performed on the other half 15\u00a0days apart, randomly. Efficacy, adverse effects, cosmetic outcome and recurrence were recorded at follow\u2010up visit at 1, 3, 6 and 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Photodynamic therapy with 5 methyl\u2010aminolevulinate was more effective than trichloroacetic acid although less tolerated by patients as it was more painful. Early adverse effects were almost the same even if trichloroacetic acid leads also to crust formation and to a worse cosmetic outcome characterized by hypopigmentation. Recurrence was lower in the area treated with photodynamic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Trichloroacetic acid 50% is less effective than photodynamic therapy with 5 methyl\u2010aminolevulinate in the treatment of multiple actinic keratosis of the scalp although better tolerated by patients. As this technique is less painful and less expensive than photodynamic therapy, we hypothesize and suggest that more sequential treatments could lead to better results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12164","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T05:45:58Z","timestamp":1423287958000},"page":"233-238","source":"Crossref","is-referenced-by-count":15,"title":["Comparative study of trichloroacetic acid vs. photodynamic therapy with topical 5\u2010aminolevulinic acid for actinic keratosis of the scalp"],"prefix":"10.1111","volume":"31","author":[{"given":"Sergio","family":"Di Nuzzo","sequence":"first","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cortelazzi","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Boccaletti","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Zucchi","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Conti","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Montanari","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Feliciani","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Fabrizi","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calogero","family":"Pagliarello","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Clinical and Experimental Medicine Parma University Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11085.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57415"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0023-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12535"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01091.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01902.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.3.321"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2006.09.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07860.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07426.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.119649"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510032887"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00401.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082403"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80065-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07470.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03670.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70114-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10098.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1996.tb01868.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10209.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13138"}],"container-title":["Photodermatology, Photoimmunology &amp; 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