{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:31:41Z","timestamp":1783207901058,"version":"3.54.6"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Summary<\/jats:title>\n \n Background\/Purpose<\/jats:title>\n \n Ultraviolet A1 (\n UVA<\/jats:styled-content>\n 1) phototherapy has been used for over 15\u00a0years in the United States, primarily for the treatment of localized sclerosis and various sclerosing disorders. The objective was to describe use of\n UVA<\/jats:styled-content>\n 1 for dermatoses beyond localized sclerosis at two academic institutions.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data from 83 patients treated with low\u2010 (20\u201340\u00a0J\/cm\n 2<\/jats:sup>\n ), medium\u2010 (>40\u201380\u00a0J\/cm\n 2<\/jats:sup>\n ), and high\u2010 (>80\u2013120\u00a0J\/cm\n 2<\/jats:sup>\n ) dose\n UVA<\/jats:styled-content>\n 1 phototherapy was retrospectively analyzed. The mean individual treatment dose (J\/cm\n 2<\/jats:sup>\n ), the mean number of sessions, and the mean total dose (J\/cm\n 2<\/jats:sup>\n ) were evaluated. Effectiveness was assessed by reviewing clinical examination notes from office visits.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Good therapeutic efficacy was seen in patients with systemic sclerosis (\n SS<\/jats:styled-content>\n , 16 patients), graft\u2010versus\u2010host disease (\n GVHD<\/jats:styled-content>\n , 25 patients), and nephrogenic systemic fibrosis (\n NSF<\/jats:styled-content>\n , 17 patients). A statistically significant a dose\u2013response association was observed in the cases of\n SS<\/jats:styled-content>\n ,\n GVHD<\/jats:styled-content>\n and\n NSF<\/jats:styled-content>\n . Likelihood of clinical improvement from\n UVA<\/jats:styled-content>\n 1 phototherapy was very likely for medium\u2010 and high\u2010dose regimens in\n SS<\/jats:styled-content>\n , while this level of improvement was only observed in\n GVHD<\/jats:styled-content>\n and\n NSF<\/jats:styled-content>\n patients receiving high\u2010dose\n UVA<\/jats:styled-content>\n 1.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n UVA<\/jats:styled-content>\n 1 phototherapy is effective and safe in the treatment of\n GVHD<\/jats:styled-content>\n ,\n NSF<\/jats:styled-content>\n ,\n SS<\/jats:styled-content>\n , and mast cell disorders. High\u2010dose regimens appear to be more effective than medium\u2010 and low\u2010dose regimens for\n NSF<\/jats:styled-content>\n and\n GVHD<\/jats:styled-content>\n , while medium\u2010 and high\u2010dose regimens outperform low\u2010dose\n UVA<\/jats:styled-content>\n 1 in\n SS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/phpp.12185","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T11:31:26Z","timestamp":1433590286000},"page":"289-295","source":"Crossref","is-referenced-by-count":37,"title":["Ultraviolet A1 phototherapy beyond morphea: experience in 83 patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Karen L.","family":"Connolly","sequence":"first","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"McEvoy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry W.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80277-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00245.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00422.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00570.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.105165"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08672.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121352"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.02.011"},{"key":"e_1_2_7_10_1","first-page":"1169","article-title":"Prospects for ultraviolet A1 phototherapy as a treatment for chronic cutaneous graft\u2010versus\u2010host disease","volume":"88","author":"Calzavara Pinton P","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04427.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.245"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.11.1527"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12616142"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)62472-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05261.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001050170085"}],"container-title":["Photodermatology, Photoimmunology & Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphpp.12185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:09:21Z","timestamp":1695470961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/phpp.12185"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12185","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725540872.793507343","asserted-by":"object"}]},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}