{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T21:15:08Z","timestamp":1715202908418},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Photochemochemotherapy with 8\u2010methoxypsoralen and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A light (<jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>) is a well\u2010established treatment for mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>), although evidence for this therapy by means of prospective studies is scarce. However, long\u2010term risks of <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> are premature skin aging and development of nonmelanoma skin cancer. We therefore evaluated a device for targeted <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> therapy, which reduces irradiation of unaffected skin in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients with patch\u2010 or plaque\u2010type <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> affecting less than 10% body surface area were included in a prospective study. A total of 14 lesions were treated with cream <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> using the digital phototherapy device skintrek<jats:sup>\u00ae<\/jats:sup> <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven of ten patients showed response to treatment. Complete clinical remission was achieved in four of ten patients (complete remission of seven of fourteen treated lesions) after an average of 13.4\u00a0weeks and an average cumulative <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> dose of 42.6\u00a0J\/cm<jats:sup>2<\/jats:sup> in a mean of 31.2 treatment sessions. Adverse events were rare and of mild severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is the first prospective trial demonstrating efficacy and safety of cream <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients. As healthy adjacent skin remains unaffected, the potential to reduce the carcinogenic risk of <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> treatment makes this new method a promising therapeutic option for localized <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12196","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T13:13:32Z","timestamp":1439903612000},"page":"333-340","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of localized mycosis fungoides with digital <scp>UV<\/scp> photochemotherapy"],"prefix":"10.1111","volume":"31","author":[{"given":"Ulrich","family":"Reidel","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Skin cancer centre Charit\u00e9 Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bechstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Skin cancer centre Charit\u00e9 Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Lange\u2010Asschenfeldt","sequence":"additional","affiliation":[{"name":"Department of Dermatology State Hospital Klagenfurt Klagenfurt Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Skin cancer centre Charit\u00e9 Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Vandersee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Skin cancer centre Charit\u00e9 Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Department of Dermatology and Allergy Central German armed forces hospital Koblenz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.729831"},{"key":"e_1_2_7_3_1","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze 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