{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:49:38Z","timestamp":1772527778291,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish \u201cFondo de Investigaci\u00f3n Sanitaria'","award":["PI11\/00767"],"award-info":[{"award-number":["PI11\/00767"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) infection has been reported to be a risk factor for porphyria cutanea tarda (<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the strength of the association between <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection and <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> in a large hospital setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients (<jats:italic>N<\/jats:italic>\u00a0=\u00a0210) diagnosed of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> between 1990 and 2014 were retrospectively investigated for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection and co\u2010precipitating factors. High\u2010performance liquid chromatography was used to assess the appearance of pre\u2010<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> urinary porphyrin abnormalities among a group (<jats:italic>N<\/jats:italic>\u00a0=\u00a022) of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients without <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> using the urine of patients co\u2010infected with hepatitis C virus (HCV) without <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients (19 males and seven females) were diagnosed of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>. During the same interval of time, ~8000 different patients infected with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> were attended in the hospital of infectious diseases department. Examination of risk factors showed that 25 out of 26 of the <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> were co\u2010infected with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. No chromatographic abnormalities were found in the urine of non\u2010<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients, whereas 39% co\u2010infected patients showed urinary porphyrin abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our large hospital series, the appearance of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> among <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients is low (&lt;1%) and most present co\u2010infection with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. Therefore, in most <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients with PCT, hepatitis C and not <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> may induce uroporphyrinogen decarboxylase deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12222","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T13:40:47Z","timestamp":1447854047000},"page":"93-97","source":"Crossref","is-referenced-by-count":13,"title":["Human immunodeficiency virus and risk of porphyria cutanea tarda: a possible association examined in a large hospital"],"prefix":"10.1111","volume":"32","author":[{"given":"Paula","family":"Aguilera","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Clinic IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Laguno","sequence":"additional","affiliation":[{"name":"Infectious Disease Department Hospital Clinic IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"To\u2010Figueras","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department Hospital Cl\u00ednic IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007142"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02794.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160603"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830250112"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199009000-00017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.889955"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4065\/73.9.895"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1997.tb00116.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05489.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-93"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/archderm.1996.03890320054009","article-title":"Abnormal serum porphyrin levels in patients with the acquired immunodeficiency syndrome with or without hepatitis C virus infection","volume":"132","author":"Nomura N","year":"1996","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(84)90192-X"},{"key":"e_1_2_6_14_1","first-page":"251","article-title":"Long\u2010standing changes in the urinary profile of porphyrin isomers after clinical remission of porphyria cutanea tarda","volume":"33","author":"To\u2010Figueras J","year":"2003","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181d50928"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13376"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1001\/archderm.1996.03890360034007","article-title":"Abnormal urinary coproporphyrin levels in patients infected by hepatitis C virus with or without human immunodeficiency virus","volume":"132","author":"Cribier B","year":"1996","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328216f379"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199510000-00003"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphpp.12222","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:55:31Z","timestamp":1695549331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/phpp.12222"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12222","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,15]]}}}