{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:59:09Z","timestamp":1770267549932,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002468","name":"Dong-A University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002468","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic actinic dermatitis (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) has a more complicated pathogenetic basis than others. The clinical grading system and its correlations with the clinical and immunological parameters still remained to be investigated to define the nature of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> in a more detailed manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated correlations of the clinical severity score of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) with the clinical and immunological parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 72 patients with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> and classified them into three groups according to the <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. We analysed total IgE level, peripheral blood (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) eosinophil count, the ratio of Th2cell (<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>4\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\u00a0+) percentage over Th1 cell (<jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>3\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\u00a0+) percentage (Th2\/Th1) and\/or the sum of suppressor\/cytotoxic T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total IgE levels and the percentage of <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> eosinophils were higher in the severer group than other groups. A shift towards Th2 from Th2\/Th1 balanced status may be affected by total counts of suppressor T cells, and the patient with higher Th2\/Th1 ratio than balanced status had the more proportion in the severer <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> group than other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> correlates with total IgE level, <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> eosinophil count and a shift towards Th2 immunity from Th2\/Th1. So we suggest the Th1\/Th2 dysbalance may be affected by the <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12244","type":"journal-article","created":{"date-parts":[[2016,4,16]],"date-time":"2016-04-16T10:06:40Z","timestamp":1460801200000},"page":"199-206","source":"Crossref","is-referenced-by-count":24,"title":["The clinical severity score of chronic actinic dermatitis correlates with <i>in\u00a0vivo<\/i> photoallergic reactions and the immunologic parameters related to a shift towards Th2 immunity from the Th2\/Th1 balanced status in patients with chronic actinic dermatitis"],"prefix":"10.1111","volume":"32","author":[{"given":"Dong\u2010Yeob","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Dermatology Dong\u2010A University College of Medicine Busan 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