{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:17:33Z","timestamp":1788445053313,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In mastocytosis, the skin is almost invariably involved, and cutaneous symptoms deeply affect patients' quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational analysis of patients affected by cutaneous mastocytosis (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) and indolent systemic mastocytosis (<jats:styled-content style=\"fixed-case\">ISM<\/jats:styled-content>) treated with phototherapy\/photochemotherapy (<jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) has been conducted. For each patient, total numbers of <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> exposures, the cumulative <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> dose (J\/cm<jats:sup>2<\/jats:sup>), serum tryptase profile, and pruritus, before and after treatment, according to the visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) were considered. Skin lesions of each patient were assessed, before and after treatment, according to a cutaneous scale score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients affected by <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ISM<\/jats:styled-content> were studied; in particular, 10 patients received <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> therapy, and other 10 patients received <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>. A statistically significant mean reduction of pruritus in both groups (<jats:italic>P<\/jats:italic> &lt; 0.01) was observed. The number of treatments necessary to obtain symptom relief was significantly lower in the <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> group, but the mean exposure dose was significantly higher, if compared to the <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> group. Serum tryptase levels showed a downward trend. The cutaneous score improved in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>This study was a retrospective study with a small sample size and without a control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work provides evidence that both <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> represent a safe and useful second\u2010line therapy of the cutaneous symptoms in mastocytosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12248","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T08:25:27Z","timestamp":1467188727000},"page":"238-246","source":"Crossref","is-referenced-by-count":39,"title":["Narrow\u2010band <scp>UVB<\/scp> phototherapy and psoralen\u2013ultraviolet A photochemotherapy in the treatment 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