{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:05:49Z","timestamp":1761311149448},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Urocanic acid (<jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content>) absorbs ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>)B radiation in the epidermis which may interfere with phototherapy. Therefore, the influence of individual levels of <jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content> on immune reactivity and vitamin D synthesis induced by narrowband <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> radiation was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight subjects with irritant contact dermatitis of the hands were irradiated with suberythemal doses of narrowband <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> radiation on their unaffected lower forearms on three consecutive days. S<jats:italic>tratum corneum<\/jats:italic> tape strips and epidermal interstitial fluid (<jats:styled-content style=\"fixed-case\">ISF<\/jats:styled-content>) as well as blood samples were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Narrowband <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation led to the conversion of <jats:italic>trans<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content> into its <jats:italic>cis<\/jats:italic>\u2010isomer in the epidermis. The observed increase in 25\u2010hydroxyvitamin D serum concentrations was inversely correlated with the baseline levels of <jats:italic>trans\u2010<\/jats:italic><jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content>. Furthermore, <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation induced significant changes in the levels of <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>10\/<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2\/<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>4\/<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b2, and the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b1 ratio. The levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b1 and <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>9\/<jats:styled-content style=\"fixed-case\">MIG<\/jats:styled-content> showed a trend toward increase. The changes in the levels of inflammatory and immunomodulatory mediators did not depend on baseline levels of <jats:italic>trans<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that epidermal levels of <jats:italic>trans<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content> affect vitamin D synthesis, but not cutaneous immune reactivity upon repeated exposure to suberythemal doses of narrowband <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> radiation. However, this requires further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12249","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T17:46:59Z","timestamp":1467308819000},"page":"214-223","source":"Crossref","is-referenced-by-count":24,"title":["The effect of epidermal levels of urocanic acid on 25\u2010hydroxyvitamin D synthesis and inflammatory mediators upon narrowband <scp>UVB<\/scp> irradiation"],"prefix":"10.1111","volume":"32","author":[{"given":"Lilla","family":"Landeck","sequence":"first","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck Osnabr\u00fcck Germany"},{"name":"Department of Dermatology Ernst von Bergmann General Hospital Teaching Hospital Charit\u00e9 University Medicine Berlin Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivone","family":"Jakasa","sequence":"additional","affiliation":[{"name":"Laboratory for Analytical Chemistry Department of Chemistry and Biochemistry Faculty of Food Technology and Biotechnology University of Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Dapic","sequence":"additional","affiliation":[{"name":"Laboratory for Analytical Chemistry Department of Chemistry and Biochemistry Faculty of Food Technology and Biotechnology University of Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Lutter","sequence":"additional","affiliation":[{"name":"Departments of Respiratory Medicine and Experimental Immunology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology University Medical Center G\u00f6ttingen Georg August University G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck and University Medical Center G\u00f6ttingen Osnabr\u00fcck\/G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology University Medical Center G\u00f6ttingen Georg August University G\u00f6ttingen 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