{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:40:35Z","timestamp":1791999635339,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dermatology Department of the Hospital Central Dr. Ignacio Morones Prieto, San Luis Potos\u00ed, M\u00e9xico"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Vitiligo is the most commonly acquired depigmentation disorder of the skin and is characterized by the destruction of melanocytes. Ultraviolet phototherapy with narrow band (UVB\u2010NB) induces proliferation, differentiation, maturation, and migration of melanocytes. The clinical repigmentation is featured by follicular, marginal, and diffuse patterns. The aim of this study was to observe the process involved in the melanocyte migration and proliferation among these patterns and the unresponsive lesions following UVB\u2010NB phototherapy. The focal adhesion kinase (FAK) and c\u2010KIT were used as markers of melanocyte migration and differentiation, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 17 vitiligo patients under UVB\u2010NB therapy were selected. The patients expressed the three repigmentation patterns as well as unresponsive lesions at the conclusion of a 30\u2010session cycle. Skin biopsies were evaluated by immunohistochemistry and qRT\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found an increased expression of c\u2010KIT in the follicular pattern compared to the diffuse pattern that was expressed predominantly of FAK. Marginal pattern expressed both proteins. The unresponsive achromic lesions showed poor expressions of both markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Proliferation was prominent in the follicular pattern, but migration was prominent in the diffuse pattern. For the marginal pattern, both dynamics were present. The absence of these markers in vitiligo lesions suggests a lack of response to UVB\u2010NB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12275","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T06:52:41Z","timestamp":1473922361000},"page":"269-275","source":"Crossref","is-referenced-by-count":9,"title":["Repigmentation patterns induced by NB\u2010UVB and their relationship with melanocytic migration and proliferation in vitiligo"],"prefix":"10.1111","volume":"32","author":[{"given":"Juan Pablo","family":"Castanedo\u2010C\u00e1zares","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Central Dr. Ignacio Morones Prieto Universidad Aut\u00f3noma de San Luis Potos\u00ed San Luis Potos\u00ed M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Diego","family":"Cort\u00e9s\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Cellular and Molecular Biology 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