{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:30Z","timestamp":1787015970460,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin hyperpigmentary disorders including postinflammatory hyperpigmentation, melasma, solar lentigines, and conditions like freckles are common. The light\u2010emitting diodes (LEDs) are the latest category of nonthermal and noninvasive phototherapy to be considered in skin pigmentation disorder treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The purpose of this study was to investigate the effects of 660\u2010nm LED on inhibition of melanogenesis. We investigated whether a 660\u2010nm LED affected melanin synthesis in\n                      <jats:italic>in\u00a0vitro<\/jats:italic>\n                      and\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      models, and we explored the mechanisms involved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The inhibitory effect of 660\u2010nm LED on melanin synthesis was evaluated in B16F10 cells and HRM\u20102 melanin\u2010possessing hairless mice were used to evaluate the antimelanogenic effects of 660\u2010nm LED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Interestingly, 660\u2010nm LED inhibited alpha\u2010melanocyte\u2010stimulating hormone\u2010induced tyrosinase activity in B16F10 cells. We also found that 660\u2010nm LED decreased MITF and tyrosinase expression and induced the activation of ERK. These findings suggest that the depigmenting effects of 660\u2010nm LED result from downregulation of MITF and tyrosinase expression due to increased ERK activity. The 660\u2010nm LED reduced UVB\u2010induced melanogenesis in the skin of HRM\u20102 via downregulation of tyrosinase and MITF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest 660\u2010nm LED is a potentially depigmentation strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.12276","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T08:39:53Z","timestamp":1475829593000},"page":"49-57","source":"Crossref","is-referenced-by-count":23,"title":["Inhibitory effect of 660\u2010nm LED on melanin synthesis in\n                    <i>in\u00a0vitro<\/i>\n                    and\n                    <i>in\u00a0vivo<\/i>"],"prefix":"10.1111","volume":"33","author":[{"given":"Chang Taek","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"},{"name":"Department of Medicine Graduate School Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-7714","authenticated-orcid":false,"given":"Tae\u2010Rin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ja","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Re","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul 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