{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:14:59Z","timestamp":1791389699350,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8157120310"],"award-info":[{"award-number":["8157120310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment of vitiligo is still one of the most difficult dermatological challenges, although there are many therapeutic options. Narrow band ultraviolet B (<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) phototherapy is considered to be a very important modality for generalized vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to explore whether a combination of <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> and topical agents would be superior to <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> alone for treating vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the electronic databases such as <jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, Cochrane Library, and Web of Science. The primary outcome was the proportion of \u226550% repigmentation (a clinical significance), and secondary outcome was the proportion of \u226575% repigmentation (an excellent response).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) involving 240 patients (413 lesions) were included in this meta\u2010analysis. The study showed no significant difference between <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> combination therapy (<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> and topical calcineurin inhibitor or vitamin D analogs) and <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> monotherapy in the outcomes of \u226550% repigmentation and \u226575% repigmentation. However, lesions located on the face and neck had better results in \u226550% repigmentation (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a01.40, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.08\u20131.81) and \u226575% repigmentation (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a01.88, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.10\u20133.20) with <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> and topical calcineurin inhibitor combination therapy vs. <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The meta\u2010analysis suggested that adding neither topical calcineurin inhibitors nor topical vitamin\u2010D3 analogs on <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> can yield significantly superior outcomes than <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> monotherapy for treatment of vitiligo. However, addition of topical calcineurin inhibitors to <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> may increase treatment outcomes in vitiligo affecting face and neck.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12277","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T12:39:54Z","timestamp":1475843994000},"page":"22-31","source":"Crossref","is-referenced-by-count":53,"title":["Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Ronghua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology Qilu Hospital Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Qilu 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