{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:29:40Z","timestamp":1779910180110,"version":"3.53.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Actinic cheilitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) is a lip intraepithelial neoplasia, whose cells present alterations similar to those presented by invasive squamous cell carcinomas (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To conduct clinical and laboratory evaluation by histopathology and immunohistochemistry of the efficacy of actinic cheilitis treatment using photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) with methyl aminolevulinate (<jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>) and noncoherent red light.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Patients with actinic cheilitis detected by histopathological examination were submitted to two sessions of photodynamic therapy with a two\u2010week interval between them. They were examined immediately after the sessions, four, six, and twelve weeks after beginning treatment when a new biopsy was carried out. Clinical histopathological and immunohistochemical parameters were evaluated before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 23 patients who underwent biopsy, 16 completed two photodynamic therapy sessions and the material of one patient was insufficient for immunohistochemistry. Complete clinical response was achieved in 62.5% (10 of 16 patients) and 37.5% still remained with clinical evidence of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>. In spite of this, no case of cure by histopathological analysis was found. There was no significant statistical change among the values of Ki\u201067, survivin, and p53 observed before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Photodynamic therapy, as carried out in this trial, was not an efficacious therapeutic option for treating patients with actinic cheilitis included in this sample.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12281","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T14:06:35Z","timestamp":1479564395000},"page":"14-21","source":"Crossref","is-referenced-by-count":34,"title":["Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis"],"prefix":"10.1111","volume":"33","author":[{"given":"Yuri N.","family":"Chaves","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculdade de Medicina Hospital das Clinicas Universidade de Sao Paulo Sao Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Antonio","family":"Torezan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculdade de Medicina Hospital das Clinicas Universidade de Sao Paulo Sao Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Vanessa","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculdade de Medicina Hospital das Clinicas Universidade de Sao Paulo Sao Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyro Festa","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculdade de Medicina Hospital das Clinicas Universidade de Sao Paulo Sao Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"113","article-title":"Actinic cheilitis and carcinoma of the lip","volume":"60","author":"Main JHP","year":"1994","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70115-0"},{"key":"e_1_2_5_4_1","first-page":"733","article-title":"Tobacco carcinogens, their biomarkers and tobacco induced cancer","volume":"3","author":"Hecht SS","year":"2003","journal-title":"Nature"},{"key":"e_1_2_5_5_1","first-page":"22","article-title":"Oral mucosal lesions and risk habits among men in an Italian study population","volume":"31","author":"Campisi G","year":"2002","journal-title":"J Oral Pathol M\u00e9d"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988008800311"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01004.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1981.tb00203.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31217"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00440.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1524-4725.1997.tb00002.x","article-title":"Actinic cheilitis: a treatment review","volume":"23","author":"Dufrense R","year":"1997","journal-title":"Dermatol Surg"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.07.012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1020.x"},{"key":"e_1_2_5_14_1","first-page":"548","article-title":"Geronemus. 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