{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:20:04Z","timestamp":1790065204705,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of our study was to examine the effects of photobiomodulation therapy (PBMT) in the treatment of breast cancer\u2010related lymphedema using a compactly designed treatment regime consisting of eight therapy sessions in combination with a cluster laser device covering a total area size of 78.54\u00a0cm\u00b2 over the axillary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with unilateral lymphedema were enrolled in this double\u2010blind, placebo\u2010controlled trial in order to evaluate effects of PBMT on lymphedema\u2010related pain, quality of life, grip strength and limb volume difference. Subjects received irradiation for ten minutes per session using a cluster laser covering a beam area of 78.54\u00a0cm\u00b2. The applied energy was 384 Joules resulting in an energy density of 4.89\u00a0J\/cm\u00b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010treatment, a 50% reduction in median pain scores and an increase in mean quality of life were observed. Mean grip strength was persistently higher after eight sessions of PBMT compared with pretreatment; however, no statistically significant intergroup differences (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) were found over the time course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PBMT using a compactly designed treatment regime in combination with a cluster laser device did not significantly improve quality of life, pain scores, grip strength and limb volume over the time course.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12284","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T13:01:16Z","timestamp":1481374876000},"page":"32-40","source":"Crossref","is-referenced-by-count":33,"title":["Photobiomodulation therapy in breast cancer\u2010related lymphedema: a randomized placebo\u2010controlled trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Maximilian Andreas","family":"Storz","sequence":"first","affiliation":[{"name":"Medical Faculty The Saarland University Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gronwald","sequence":"additional","affiliation":[{"name":"Centre of Palliative Care and Pediatric Pain The Saarland University Hospital Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Gottschling","sequence":"additional","affiliation":[{"name":"Centre of Palliative Care and Pediatric Pain The Saarland University Hospital Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Sch\u00f6pe","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Epidemiology and Medical Informatics The Saarland University Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russalina","family":"Mavrova","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The Saarland University Hospital Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Baum","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The Saarland University Hospital Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000257149.42922.7e"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-013-0201-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2012.11.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70076-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010915)92:6<1368::AID-CNCR1459>3.0.CO;2-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.2.96"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-012-2364-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2012.11.004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010016\u20102056\u2010y"},{"key":"e_1_2_8_11_1","first-page":"41","article-title":"Low\u2010level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring","volume":"32","author":"Avci P","year":"2013","journal-title":"Semin Cutan Med Surg"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61522-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2012.3240"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-011-0393-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11641"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0888-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-006-0380-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215508096173"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.03.050"},{"key":"e_1_2_8_20_1","first-page":"74","article-title":"Treatment of chronic postmastectomy lymphedema with low level laser therapy: a 2.5\u00a0year follow\u2010up","volume":"31","author":"Piller NB","year":"1998","journal-title":"Lymphology"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1188\/13.ONF.383-393"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2008.2330"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1240-y"},{"key":"e_1_2_8_24_1","unstructured":"World Association for Laser Therapy. 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