{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:56Z","timestamp":1787015936241,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Photodynamic therapy (\n                    <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>\n                    ), using topical aminolevulinic acid (\n                    <jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content>\n                    ), has been used for years to treat a variety of dermatologic conditions, including actinic keratosis, superficial basal cell carcinoma, and\n                    <jats:italic>in situ<\/jats:italic>\n                    squamous cell carcinoma. While there is a wide range of neoplastic and non\u2010neoplastic skin diseases for which\n                    <jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>\n                    is used in adults, there is a knowledge gap when it comes to its use in children. This review highlights what is currently known regarding the use and efficacy of this therapy in the pediatric population. A PubMed search was conducted to identify studies including pediatric patients undergoing monotherapy\n                    <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>\n                    with topical aminolevulinate (published 2005\u20132016). Twenty pediatric articles were identified.\n                    <jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>\n                    has been used successfully in children to reduce the number and size of basal cell tumors, inflammatory acne lesions, plantar warts, and linear porokeratoses.\n                    <jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content>\n                    <jats:bold>\u2010<\/jats:bold>\n                    <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>\n                    may be an attractive alternative to surgery for children with basal cell nevus syndrome, or to conventional destructive and\/or topical methods used for plantar warts or linear porokeratoses.\n                    <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>\n                    can be considered for inflammatory acne when topical treatments have failed and systemic medications are not an option. Pain associated with treatment and insurance coverage may be a barrier to use.\n                  <\/jats:p>","DOI":"10.1111\/phpp.12296","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T02:17:02Z","timestamp":1485569822000},"page":"125-134","source":"Crossref","is-referenced-by-count":18,"title":["Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3301-8210","authenticated-orcid":false,"given":"Neha","family":"Kumar","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-1681","authenticated-orcid":false,"given":"Christine B.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cleveland Clinic Cleveland OH 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