{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:38:19Z","timestamp":1779233899979,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Galderma Research & Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) has been reported as an effective alternative treatment for patients with acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the efficacy and safety of <jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> in moderate to severe acne and to compare outcomes with those of laser\u2010assisted daylight photodynamic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomly assigned to either a <jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> group (D group) or a fractional laser\u2010assisted <jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> group (F group). The outcomes were assessed by measuring acne lesion counts and severity grade at 4, 8, 12, and 16\u00a0weeks after therapy commenced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight subjects completed the study. Compared with baseline, the mean inflammatory lesion counts significantly decreased by 36.0% in the D group and 51.8% in the F group at 8\u00a0weeks (<jats:italic>P<\/jats:italic>&lt;.001). The mean acne severity grades in both groups significantly decreased starting at 4\u00a0weeks (<jats:italic>P<\/jats:italic>=.012), and the beneficial effects lasted 16\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content> shows clinically good responses to inflammatory lesions and is well tolerated in patients with moderate to severe acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12312","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T14:56:45Z","timestamp":1494687405000},"page":"253-259","source":"Crossref","is-referenced-by-count":26,"title":["Nonablative fractional laser\u2010assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study"],"prefix":"10.1111","volume":"33","author":[{"given":"Tae In","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-9566","authenticated-orcid":false,"given":"Hye\u2010Jin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Hye","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Heon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nack In","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05673.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12031"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13191"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11200.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12974"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13138"},{"key":"e_1_2_7_8_1","unstructured":"LacourJ.Results of 2 randomised controlled phase III studies with daylight\u2010PDT in Australia and Europe. 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