{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:26:48Z","timestamp":1783117608422,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Dermatology, Medical University of Vienna, Vienna."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Actinic cheilitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) is a common disease caused by chronic ultraviolet exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Alacare is a self\u2010adhesive, skin coloured 5\u2010aminolaevulinic acid (<jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content>) patch that has been developed for the treatment of mild to moderate actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>). Considering the good results in the treatment of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>, the standardized delivery of <jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content> and the simple application Alacare patch\u2010 photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) appears as an interesting treatment option for <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed the efficacy, tolerability and cosmetic outcome of Alacare patch\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> in eleven patients with <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>. After occlusion with the Alacare patches for 4\u00a0hours, the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> lesions were illuminated with narrowband red light and a dose of 37\u00a0J\/cm<jats:sup>2<\/jats:sup>. All patients were clinically assessed for efficacy, side effects and cosmetic outcome at 3, 6, 9 and 12\u00a0months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete clinical response at the 3\u2010month follow\u2010up was achieved in eight of 11 patients (72,7%) and 12 of 15 <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> lesions (80,0%), respectively. Up to the final 12\u2010month follow\u2010up, a recurrence was observed in two lesions. The complete clinical cure rate at 1\u00a0year after Alacare patch\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, thus, was 66,6% (10\/15 lesions). The cosmetic outcome of the treatment was excellent in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alacare patch\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was found to have substantial efficacy in the treatment of mild to moderate <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>. Given its ease of use, absence of long\u2010term side effects and the excellent cosmetic results Alacare patch\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> might be considered as a promising new treatment option for the management of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12332","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T10:54:06Z","timestamp":1499943246000},"page":"306-310","source":"Crossref","is-referenced-by-count":24,"title":["5\u2010aminolaevulinic acid patch\u2010photodynamic therapy in the treatment of actinic cheilitis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-9713","authenticated-orcid":false,"given":"Sonja","family":"Radakovic","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Tanew","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01004.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04580.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000254"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33176.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09040.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09377.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03550.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10478.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12281"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2007.00299.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20470"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1610-0387.2012.08046.x","article-title":"Photodynamic therapy for skin rejuvenation: review and summery of the literature\u2010results of a consensus conference of an expert group for aesthetic photodynamic therapy","volume":"11","author":"Karrer S","year":"2013","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99166.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199609000-00007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2010.00552.x"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphpp.12332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:19:26Z","timestamp":1695557966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/phpp.12332"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12332","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}