{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:20:50Z","timestamp":1768011650286,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["BSC0111"],"award-info":[{"award-number":["BSC0111"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Ultraviolet B (UVB<\/jats:styled-content>) radiation is the major contributor to skin inflammation which leads to the development of skin cancer. Hence, in this study, we studied the effect of Nexrutine (NX<\/jats:styled-content>) on UVB<\/jats:styled-content>\u2010induced cutaneous inflammation and its mediators.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ultraviolet absorption spectra of NX<\/jats:styled-content> were measured by spectrophotometer. To conduct the photoprotective studies, SKH<\/jats:styled-content>\u20101 hairless mice were topically treated with NX<\/jats:styled-content>, 30\u00a0minutes before to the UVB<\/jats:styled-content> (180\u00a0mJ\/cm2<\/jats:sup>) exposure. Twenty hours of post\u2010UVB<\/jats:styled-content> irradiation, mouse skin was used for edema measurements, H & E staining, myeloperoxidase (MPO<\/jats:styled-content>) activity, and estimation of plasma cytokines. In addition, expression levels of inflammatory cytokines, cyclooxygenase\u20102 (COX<\/jats:styled-content>\u20102), and inducible nitric oxide synthase (iNOS<\/jats:styled-content>) were also determined by Western blot analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Nexrutine displayed absorbance over the UVB<\/jats:styled-content> spectrum. NX<\/jats:styled-content> significantly decreased the UVB<\/jats:styled-content>\u2010induced epidermal edema, skin thickness, leukocyte infiltration, number of the sunburn, and TUNEL<\/jats:styled-content>\u2010positive cells. NX<\/jats:styled-content> treatment also decreased the number of mast cells, MPO<\/jats:styled-content> activity, expression of pro\u2010inflammatory cytokines, and inflammation mediator protein in mouse skin.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These results provide evidences that NX<\/jats:styled-content> inhibits the UVB<\/jats:styled-content>\u2010induced cutaneous inflammatory responses in SKH<\/jats:styled-content>\u20101 mouse skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12348","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T11:51:54Z","timestamp":1504180314000},"page":"82-90","source":"Crossref","is-referenced-by-count":9,"title":["Topical application of Nexrutine inhibits ultraviolet B\u2010induced cutaneous inflammatory responses in SKH<\/scp>\u20101 hairless mouse"],"prefix":"10.1111","volume":"34","author":[{"given":"Shamshad","family":"Alam","sequence":"first","affiliation":[{"name":"Environmental Carcinogenesis 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