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Oral supplements that reduce sunburn may be advantageous. This study evaluated the safety and efficacy of Bend Skincare Anti\u2010Aging Formula to ameliorate sunburn induced with a solar simulator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a028) with Fitzpatrick skin phototypes I, II, or III took 4 capsules daily of the supplement providing 1400\u00a0mg of eicosapentaenoic acid (EPA)\u00a0+\u00a0docosahexaenoic acid (DHA), 120\u00a0mg of gamma\u2010linolenic acid (GLA), 5\u00a0mg of lutein, 2.5\u00a0mg of zeaxanthin, and 1000\u00a0IU of vitamin D3 for 8\u00a0weeks. Skin on each subject's back was exposed to a progressive sequence of timed ultraviolet (UV) radiation exposure doses at baseline, and after 4\u2010 and 8\u2010week treatment to determine their minimal erythema dose (MED). Results were compared before and after treatment using 3 paired <jats:italic>t<\/jats:italic> tests and subsequently 3 linear mixed models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment significantly improved tolerance to UV exposure as evidenced by increased MED at 4 and 8\u00a0weeks compared with baseline (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). This protection increased with prolonged use of Bend Skincare Anti\u2010Aging Formula as demonstrated by progressively increased MED between baseline and 4\u00a0weeks, and again between 4 and 8\u00a0weeks (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Nearly 86% of patients responded to treatment within 4\u00a0weeks and 100% of patients responded by the end of the study, resulting in a 39% mean increase in MED at 4\u00a0weeks, and an 84% mean increase in MED at 8\u00a0weeks compared with baseline. Treatment was well tolerated with no product associated adverse events (AE) and only a few mild and expected side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bend Skincare Anti\u2010Aging Formula safely and effectively provides significant skin photoprotection that increases with continued use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12350","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T10:56:40Z","timestamp":1504868200000},"page":"152-161","source":"Crossref","is-referenced-by-count":7,"title":["An open\u2010label clinical trial assessing the efficacy and safety of Bend Skincare Anti\u2010Aging Formula on minimal erythema dose in skin"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-6225","authenticated-orcid":false,"given":"Nancy L.","family":"Morse","sequence":"first","affiliation":[{"name":"Independent Scientific Consultant  Berwick NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Jean","family":"Reid","sequence":"additional","affiliation":[{"name":"Bend Beauty Inc.  Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"St\u2010Onge","sequence":"additional","affiliation":[{"name":"Bend Beauty Inc.  Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Health effects of UV radiation. United States:Environmental Protection Agency;2017.http:\/\/www.epa.gov\/sunsafety\/health-effects-uv-radiation. Accessed March 27 2017."},{"key":"e_1_2_8_3_1","unstructured":"Canadian Partnership Against Cancer.The economic burden of skin cancer in Canada: current and projected Canada: Canadian Cancer Society;2010Feb 26.http:\/\/www.cancer.ca\/en\/get-involved\/take-action\/what-we-are-doing\/financial-hardship-of-cancer-in-canada-mb\/?region=mb. 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