{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:12:13Z","timestamp":1774307533716,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Summary<\/jats:title>Background\/Purpose<\/jats:title>Vitamin D has a role in variety of autoimmune diseases including vitiligo. Narrow\u2010band UVB<\/jats:styled-content> (NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> effects on immunohistochemical vitamin D receptor (VDR<\/jats:styled-content>) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response.<\/jats:p><\/jats:sec>Methods<\/jats:title>Using immunohistochemistry, VDR<\/jats:styled-content> expression was estimated in skin biopsies of 30 controls and 30 vitiligo patients; from vitiligo lesion, perilesional skin at baseline and from repigmented and nonresponding skin after 24 NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> sessions. Baseline serum 25\u2010hydroxyvitamin D [25(OH<\/jats:styled-content>)D] was investigated and repeated after 24 NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> sessions.<\/jats:p><\/jats:sec>Results<\/jats:title>Vitamin D receptor expression and serum 25(OH<\/jats:styled-content>)D in controls were significantly higher compared to vitiligo patients. After NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> therapy, there was a significant rise in VDR<\/jats:styled-content> expression and serum 25(OH<\/jats:styled-content>)D. VDR<\/jats:styled-content> expression was significantly higher in repigmented skin compared to nonresponding lesion. Improvement in the clinical outcome score was associated with higher baseline VDR<\/jats:styled-content> expression and higher serum 25(OH<\/jats:styled-content>)D.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> phototherapy is associated with improved cutaneous VDR<\/jats:styled-content> expression and vitamin D synthesis. Better repigmentation response to NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content> may be related to higher baseline VDR<\/jats:styled-content> expression and its upregulation after phototherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12362","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T14:16:35Z","timestamp":1509200195000},"page":"175-183","source":"Crossref","is-referenced-by-count":15,"title":["Narrow\u2010band UVB<\/scp> effects on cutaneous vitamin D receptor expression and serum 25\u2010hydroxyvitamin D in generalized vitiligo"],"prefix":"10.1111","volume":"34","author":[{"given":"Hala M.","family":"El\u2010hanbuli","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Fayoum University Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-7555","authenticated-orcid":false,"given":"Noha M.","family":"Dawoud","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology and STDs Menoufia University Shebin Elkoom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania H.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and molecular biology Faculty of Medicine Fayoum University Fayoum 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