{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:06:11Z","timestamp":1791821171618,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP \u2010 2014\/26988\u20105"],"award-info":[{"award-number":["FAPESP \u2010 2014\/26988\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cutaneous hyperchromias are disorders of skin pigmentation involving increased melanin production and its irregular accumulation in skin cells. The use of sunscreens is fundamental for the control of hyperchromias by reducing the stimulation of pigmentation, as melanin synthesis is mainly stimulated by solar radiation. Many studies have demonstrated that visible light can induce significant skin damage. Considering the effects of visible light, effective photoprotection should not be limited only to <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> protection but should also involve visible and infrared protection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">VIS<\/jats:styled-content> sunscreens in protecting skin against damages caused by solar radiation and the influence of visible light on the appearance of cutaneous hyperchromias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty volunteers aged 18 to 39\u00a0years with skin hyperpigmentation participated in the study. To evaluate the efficacy of the formulations developed, the percentage of hyperpigmented area was evaluated using high\u2010resolution images\u2014Visioface<jats:sup>\u00ae<\/jats:sup> Quick (Courage\u2010Khazaka, Germany) and the analysis of epidermal pigmentation was performed by <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\u2014Vivascope<jats:sup>\u00ae<\/jats:sup> 1500 (Lucid, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>). Also, the melanin index was determined using the Mexameter<jats:sup>\u00ae<\/jats:sup> M X16 colorimeter (Courage\u2010Khazaka, Germany).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The developed formulations were effective in the reduction in melanin index, epidermal pigmentation, and percentage of hyperpigmented area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Finally, this study discusses how the combination of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> filters and pigments can protect the skin from solar radiation and reduces skin hyperpigmentations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12377","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T18:44:43Z","timestamp":1517337883000},"page":"241-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Influence of visible light on cutaneous hyperchromias: Clinical efficacy of broad\u2010spectrum sunscreens"],"prefix":"10.1111","volume":"34","author":[{"given":"Ana Paula M.","family":"Martini","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6678-1207","authenticated-orcid":false,"given":"Patricia M. 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