{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:13:12Z","timestamp":1784563992966,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Narrowband\u2010ultraviolet B (<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) is widely used for the treatment of several dermatological diseases. A cutaneous carcinogenic effect has been hypothesized, but not proved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the data of patients treated with <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> between January 1998 and December 2013 at the Dermatology Unit of our University Hospital, to evaluate the cutaneous carcinogenic risk of <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 375 patients were included, each receiving a mean follow\u2010up of 6.9\u00a0years. Vitiligo and psoriasis were the most common diseases. In total, 19 non\u2010melanoma skin cancers (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>s) were diagnosed in eight patients, after a mean latency of 5.2\u00a0years after the first radiation. No malignant melanoma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) was observed. The incidence rates of basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) and squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) were 620.2\/100 \u0307000 p\/y and 116.3\/100 \u0307000 p\/y. <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>s were more frequent in patients affected by psoriasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0232), with older age at the first radiation (mean\u00a0=\u00a068.8\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the small number of patients and limited follow\u2010up, our data suggest that <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> may trigger cutaneous carcinogenesis, mainly in patients at risk for <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>s, increasing their personal risk for single and multiple neoplasms, usually superficial <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>s. <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> risk does not seem to be enhanced.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12382","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T11:05:21Z","timestamp":1521111921000},"page":"302-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cutaneous carcinogenic risk evaluation in 375 patients treated with narrowband\u2010<scp>UVB<\/scp> phototherapy"],"prefix":"10.1111","volume":"34","author":[{"given":"Beatrice","family":"Raone","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Experimental, Diagnostic and Specialty Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Patrizi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Experimental, Diagnostic and Specialty Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Gurioli","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Experimental, Diagnostic and Specialty Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gazzola","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Experimental, Diagnostic and Specialty Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5700-326X","authenticated-orcid":false,"given":"Giulia Maria","family":"Ravaioli","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Experimental, Diagnostic and Specialty Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(98)00139-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1989.46"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92137-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.19902071.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.026"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890480034005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05498.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05114-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00147.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.7.836"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890480045006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13703"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"8","article-title":"Italian cancer figures\u2013report 2006: 1. 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