{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:57:34Z","timestamp":1781578654806,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Phototherapy is one of the main treatments for mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>). In this study, we analyzed the efficacy and safety of phototherapy as a first\u2010line treatment in patients with early\u2010stage disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed treatment outcomes in a group of 227 early\u2010stage patients. The chi\u2010squared test, the parametric <jats:italic>t<\/jats:italic> test, and <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content> test and the non\u2010parametric tests of Mann\u2010Whitney and Kruskal\u2010Wallis were applied for data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>55.9% of patients treated with <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> reached complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>), while analog rates after <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> treatment were 74.5% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015). Patients with patch\u2010stage disease showed better response rates to <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> therapy (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>s 56.7% vs 91.3%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Regarding the latter, long\u2010lasting disease was proven as an independent negative prognostic factor for treatment outcome. Phototypes I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> were found to be favorable prognostic factors for patients treated with <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>. Maintenance treatment did not alter final relapse rates but led to prolonged time to relapse compared to no\u2010maintenance treated cases (19.5\u00a0months, vs 32.3, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our analysis indicates that <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> leads to better responses and longer relapse\u2010free intervals both in patch\u2010 and plaque\u2010stage disease. <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> could be a valid therapeutic alternative for patients with recent disease presentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12383","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T11:05:38Z","timestamp":1521111938000},"page":"307-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Phototherapy as a first\u2010line treatment for early\u2010stage mycosis fungoides: The results of a large retrospective analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9152","authenticated-orcid":false,"given":"Vasiliki","family":"Nikolaou","sequence":"first","affiliation":[{"name":"Cutaneous Lymphoma Clinic A. Sygros Hospital for skin diseases National &amp; Kapodestrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Sachlas","sequence":"additional","affiliation":[{"name":"Department of Statistics and Insurance Science University of Piraeus  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Papadavid","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic A. Sygros Hospital for skin diseases National &amp; Kapodestrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroditi","family":"Economidi","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic A. Sygros Hospital for skin diseases National &amp; Kapodestrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Karambidou","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic A. Sygros Hospital for skin diseases National &amp; Kapodestrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Marinos","sequence":"additional","affiliation":[{"name":"Haemopathology Department Evangelismos Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Stratigos","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic A. Sygros Hospital for skin diseases National &amp; Kapodestrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic A. 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