{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:38Z","timestamp":1787016038883,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Department, Universidad Cat\u00f3lica de Chile"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n Although progress has been made in the study of photodynamic therapy for acne, studies using current recommended therapies as active comparators are lacking.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Randomized, controlled trial involving 46 patients with moderate inflammatory facial acne, 23 patients received two sessions of\n PDT<\/jats:styled-content>\n separated by 2\u00a0weeks (\n ALA<\/jats:styled-content>\n 20% incubated 1.5\u00a0hours before red light irradiation with 37\u00a0J\/cm\n 2<\/jats:sup>\n fluence) and 23 patients received doxycycline 100\u00a0mg\/d plus adapalene gel 0.1%. In both groups, from the sixth week, we started adapalene gel 0.1% as maintenance therapy until 12\u00a0weeks of follow\u2010up. Primary end point was the reduction of acne lesions at the 6\u2010week follow\u2010up, which was evaluated by 2 investigators blinded to the intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median percent reductions in noninflammatory lesion count (\n P<\/jats:italic>\n \u00a0=\u00a00.013) and total lesions (\n P<\/jats:italic>\n \u00a0=\u00a00.038) at 6\u00a0weeks was found to be significantly higher in the group receiving\n PDT<\/jats:styled-content>\n . At 12\u00a0weeks there was a greater reduction of inflammatory lesions in\n PDT<\/jats:styled-content>\n group with 84% vs. 74% for group who received doxycycline plus adapalene (\n P<\/jats:italic>\n \u00a0=\u00a00.020) as well as in reducing total lesions with 79% vs. 67% respectively (\n P<\/jats:italic>\n \u00a0=\u00a00.026). No severe side\u2010effects were observed for either therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n ALA<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n offers promise as an alternative treatment for moderately severe inflammatory acne that has a higher effectiveness than the combination of doxycycline and adapalene gel in reducing noninflammatory and total lesions at 6\u00a0weeks. There were significantly superior reductions at 12\u00a0weeks in the combination of\n PDT<\/jats:styled-content>\n group followed by adapalene gel in total, inflammatory, and noninflammatory lesions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/phpp.12413","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T06:51:06Z","timestamp":1531291866000},"page":"3-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Comparison of efficacy of aminolaevulinic acid photodynamic therapy vs. adapalene gel plus oral doxycycline for treatment of moderate acne vulgaris\u2013A simple, blind, randomized, and controlled trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1432-4941","authenticated-orcid":false,"given":"Claudia","family":"Nicklas","sequence":"first","affiliation":[{"name":"Dermatology Department Universidad de La Frontera Temuco Chile"},{"name":"Dermatology Department Pontificia Universidad Cat\u00f3lica de Chile Santiago de Chile Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Rubio","sequence":"additional","affiliation":[{"name":"Dermatology Department Pontificia Universidad Cat\u00f3lica de Chile Santiago de Chile Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Dermatology Department Pontificia Universidad Cat\u00f3lica de Chile Santiago de Chile Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Hasson","sequence":"additional","affiliation":[{"name":"Dermatology Department Pontificia Universidad Cat\u00f3lica de Chile Santiago de Chile Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03340.x"},{"key":"e_1_2_6_5_1","first-page":"133","article-title":"The interaction between acne vulgaris and the psyche","volume":"70","author":"Baldwin HE","year":"2002","journal-title":"Cutis"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13675"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.078"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.1297"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14345"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.056"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.033"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15495"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01153-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90680-5"},{"key":"e_1_2_6_16_1","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER).Guidance for Industry; Acne Vulgaris: Developing Drugs for Treatment (Draft Guidance) 2005; 1\u201014. 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