{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:41:32Z","timestamp":1779234092324,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T00:00:00Z","timestamp":1534291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Actinic cheilitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) is a common, chronic premalignant condition resulting from protracted sun exposure affecting the vermilion border of the lower lip. Treatment of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> aims at terminating the progression to squamous cell carcinoma by obliterating the primary lesion, and includes ablative methods; nonablative modalities such as cryotherapy, electrodessication, chemical peeling, topical imiquimod and 5\u2010fluorouracil; and photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>). Daylight\u2010activated <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, in which natural daylight serves as the light source, showed promising results in the treatment of actinic keratoses with substantially less pain than conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the safety and efficacy of daylight <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> in a series of patients with <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients with <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> were treated with daylight <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. All patients underwent repeated treatment sessions until clinical and histological remission were achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cure rate was 91% (10 of 11 patients, three females\/eight males; mean age 59.2\u00a0\u00b1\u00a014.4\u00a0years). Mean number of treatments to attain cure was 2.7. Patients experienced mild erythema and minimal to no pain during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Daylight <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> is a promising modality for the treatment of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, with impressive cosmetic results and few side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12415","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T13:00:50Z","timestamp":1533128450000},"page":"11-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Daylight photodynamic therapy for the treatment of actinic cheilitis"],"prefix":"10.1111","volume":"35","author":[{"given":"Assi","family":"Levi","sequence":"first","affiliation":[{"name":"Photodermatosis Clinic and Laser Unit Department of Dermatology Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmilia","family":"Hodak","sequence":"additional","affiliation":[{"name":"Photodermatosis Clinic and Laser Unit Department of Dermatology Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes D.","family":"Enk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-2193","authenticated-orcid":false,"given":"Igor","family":"Snast","sequence":"additional","affiliation":[{"name":"Photodermatosis Clinic and Laser Unit Department of Dermatology Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Slodownik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine School of Public Health Department of Environmental and Occupational Health Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Lapidoth","sequence":"additional","affiliation":[{"name":"Photodermatosis Clinic and Laser Unit Department of Dermatology Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04580.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.09.040"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12526"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153848"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.43.1.7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14151"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988008800311"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.108038"},{"key":"e_1_2_7_10_1","first-page":"113","article-title":"Actinic cheilitis and carcinoma of the lip","volume":"60","author":"Main JH","year":"1994","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000100013"},{"key":"e_1_2_7_12_1","first-page":"205","article-title":"Surgical management of actinic cheilitis","volume":"6","author":"Satorres Nieto M","year":"2001","journal-title":"Med Oral"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99286.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/archderm.1977.01640070040002","article-title":"Treatment of lip keratoses (actinic cheilitis) with topical fluorouracil","volume":"113","author":"Epstein E","year":"1977","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.08.024"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572010000500018"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447386"},{"key":"e_1_2_7_18_1","unstructured":"Research C for DE and. 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