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Nail plates were softened with urea 40% by occlusive dressing for 12\u00a0hours during 3\u20107\u00a0days before treatments. Then, eight sessions separated by an interval of 2\u00a0weeks of a PDT protocol mediated by methylene blue (MB) and red laser diode (Periowave<jats:sup>\u00ae<\/jats:sup>, <jats:italic>\u03bb<\/jats:italic>\u00a0=\u00a0670\u00a0nm, 200\u00a0mW) or an IPL protocol based on 10\u00a0pulses\/cm<jats:sup>2<\/jats:sup> (Dye\u2010VL\u2010F module, Alma Lasers, <jats:italic>\u03bb<\/jats:italic>\u00a0=\u00a0500\u2010600\u00a0nm, 10\u00a0J) were applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both treatments reduced significantly the Onychomycosis Severity Index (OSI) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In terms of complete cure: 70% (PDT) and 80% (IPL) of the patients reached it after 12\u00a0weeks post\u2010treatment. No patient reported any adverse effects or complications, although in the IPL Group, some referred pain sensation during light irradiation and hematomas apparition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Photodynamic therapy and IPL were effective for onychomycosis cure of any etiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12420","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T09:58:22Z","timestamp":1535709502000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Efficiency of methylene blue\u2010mediated photodynamic therapy vs intense pulsed light in the treatment of onychomycosis in the toenails"],"prefix":"10.1111","volume":"35","author":[{"given":"Enrique","family":"Alberdi","sequence":"first","affiliation":[{"name":"Consulta privada Enrique Alberdi  Madrid 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